NEDD4L inhibits cell viability,cell cycle progression,and glutamine metabolism in esophageal squamous cell carcinoma via ubiquitination of c-Myc

查看全文 作　　者：Wei [1]Cheng;Guiyuan [2]Li;Zhou [3]Ye;Jun [1]Hu;Lixia [1]Gao;Xiaoling [1]Jia;Suping [1]Zhao;Yan [4]Wang;Qin [1]Zhou

机构地区：[1]Department of Hematologic and Oncology,Xinjiang Clinical Research Center for Precision Medicine of Digestive System Tumor,the Center Hospital of Karamay City,Karamay 834000,China;[2]Department of Oncology,Tongji Hospital,School of Medicine,Tongji University,Shanghai 200065,China;[3]Department of General Surgery,Xinjiang Clinical Research Center for Precision Medicine of Digestive System Tumor,the Center Hospital of Karamay City,Karamay 834000,China;[4]Department of Science and Education,the Center Hospital of Karamay City,Karamay 834000,China

出　　处：《Acta Biochimica et Biophysica Sinica》索引2022年第54卷第5期,共9页

基　　金：supported by the grant from the Xinjiang Uygur Autonomous Region Natural Science Foundation of China(No.2020D01A14). 摘　　要：Esophageal squamous cell carcinoma(ESCC)is a common subtype of esophageal cancer with high incidence.Surgery remains the main strategy for treatment of ESCC at early stage.However,the treatment outcome is unsatisfactory.Therefore,finding new therapeutics is of great importance.In the present study,we measured the level of NEDD4L,an ubiquitin protein ligase,in clinical samples and investigated the effects of NEDD4L on cell viability,cell cycle progression,and glutamine metabolism in TE14 cells determined by CCK-8 assay,flow cytometry and biochemical analysis,respectively.The results show that NEDD4L is significantly decreased in ESCC specimens,and its decreased expression is associated with a poor clinical outcome.Overexpression of NEDD4L significantly inhibits cell viability,cell cycle progression,and glutamine metabolism in TE14 cells.Mechanistic study indicates that NEDD4L regulates tumor progression through ubiquitination of c-Myc and modulation of glutamine metabolism.NEDD4L inhibits cell viability,cell cycle progression,and glutamine metabolism in ESCC by ubiquitination of c-Myc to decrease the expressions of GLS1 and SLC1A5.Our findings highlight the importance of NEDD4L/c-Myc signaling in ESCC. 关键词：esophageal squamous cell carcinoma glutamine metabolism NEDD4L UBIQUITINATION

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NEDD4L inhibits cell viability,cell cycle progression,and glutamine metabolism in esophageal squamous cell carcinoma via ubiquitination of c-Myc

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