Implication of gut microbiome in immunotherapy for colorectal cancer

查看全文 作　　者：Evangelos [1]Koustas;Eleni-Myrto [1]Trifylli;Panagiotis [1]Sarantis;Nikolaos [2]Papadopoulos;Georgios [2]Aloizos;Ariadne [3]Tsagarakis;Christos [4]Damaskos;Nikolaos [5]Garmpis;Anna [6]Garmpi;Athanasios G [1]Papavassiliou;Michalis V [1]Karamouzis

机构地区：[1]Department of Biological Chemistry,Medical School,National and Kapodistrian University of Athens,Athens 11527,Greece;[2]1st Department of Internal Medicine,417 Army Share Fund Hospital of Athens,Athens 11521,Attica,Greece;[3]Beth Israel Deaconess Medical Center,Boston,MA 02215,United States;[4]N.S.Christeas Laboratory of Experimental Surgery and Surgical Research,Medical School,National and Kapodistrian University of Athens,Athens 11527,Greece;[5]Second Department of Propedeutic Surgery,Laiko General Hospital,Medical School,National and Kapodistrian University of Athens,Athens 11527,Greece;[6]First Department of Pathology,Medical School,National and Kapodistrian University of Athens,Athens 11527,Greece

出　　处：《World Journal of Gastrointestinal Oncology》索引2022年第14卷第9期,共10页

摘　　要：Colorectal cancer(CRC) constitutes the third most frequently reported malignancy in the male population and the second most common in women in the last two decades. Colon carcinogenesis is a complex, multifactorial event, resulting from genetic and epigenetic aberrations, the impact of environmental factors, as well as the disturbance of the gut microbial ecosystem. The relationship between the intestinal microbiome and carcinogenesis was relatively undervalued in the last decade. However, its remarkable effect on metabolic and immune functions on the host has been in the spotlight as of recent years. There is a strong relationship between gut microbiome dysbiosis, bowel pathogenicity and responsiveness to anti-cancer treatment;including immunotherapy. Modifications of bacteriome consistency are closely associated with the immunologic response to immunotherapeutic agents. This condition that implies the necessity of gut microbiome manipulation. Thus, creatingan optimal response for CRC patients to immunotherapeutic agents. In this paper, we will review the current literature observing how gut microbiota influence the response of immunotherapy on CRC patients. 关键词：Colorectal cancer Gut microbiome IMMUNOTHERAPY Checkpoint inhibitors Tumor micro-environment

相关文献

参考文献（85）
引证文献（2）
耦合文献（377）

参考文献(85)

引证文献(2)

耦合文献(377)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Implication of gut microbiome in immunotherapy for colorectal cancer

参考文献(85)

引证文献(2)

耦合文献(377)

用户提示