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Oxygen vacancy-engineered BaTiO_(3)nanoparticles for synergistic cancer photothermal,photodynamic,and catalytic therapy

查看全文 作　　者：Yiming [1,2]Ding;Zhuo [2]Wang;Zeyu [1,2]Zhang;Yunchao [1,2]Zhao;Shangyu [3,4]Yang;Yalong [1,2]Zhang;Shuncheng [2,3]Yao;Shaobo [1,2]Wang;Tian [1,2]Huang;Yang [3,4]Zhang;Linlin [1,2,5]Li 高影响力作者 机构地区：[1]School of Chemistry and Chemical Engineering,Center on Nanoenergy Research,School of Physical Science&Technology,Guangxi University,Nanning 530004,China;[2]Beijing Institute of Nanoenergy and Nanosystems,Chinese Academy of Sciences,Beijing 100083,China;[3]Key Laboratory of Semiconductor Material Sciences,Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices,Institute of Semiconductors,Chinese Academy of Sciences,Beijing 100083,China;[4]College of Materials Science and Opto-Electronic Technology,University of Chinese Academy of Sciences,Beijing 100049,China;[5]School of Nanoscience and Technology,University of Chinese Academy of Sciences,Beijing 100049,China高影响力机构 出　　处：《Nano Research》索引2022年第15卷第8期,共9页高影响力期刊 基　　金：the National Nature Science Foundation of China(Nos.82072065 and 81471784);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA16021103);the National Youth Talent Support Program. 摘　　要：With the rapid development of photo-responsive nanomaterials,photo-triggered therapeutic strategies such as photothermal therapy(PTT)and photodynamic therapy(PDT)have been new alternatives to current cancer therapeutic methods.Herein,we have fabricated oxygen vacancy-engineered BaTiO_(3)(BTO-Ov)nanoparticles(NPs)for near-infrared(NIR)light-triggered PTT,PDT,and catalytic therapy cooperatively for significantly improving cancer therapy.Compared to pristine BaTiO_(3)nanoparticles,BTO-Ov has stronger NIR light absorption and narrower band gap structure,which results in superior photothermal conversion and superoxide radical generation capabilities through PTT and PDT.Meanwhile,due to the existence of Ti^(3+),BTO-Ov also exhibits peroxidase(POD)-like activity to produce hydroxyl radical under tumor environment,which can be further improved under 808 nm light irradiation.Both in vitro and in vivo results demonstrate that such a multifunctional therapeutic nanoplatform can achieve a high therapeutic efficacy triggered by a single NIR light irradiation.The defect engineering strategy can be used as a general approach to fabricate multifunctional cancer therapeutic nanoplatform. 关 键 词：oxygen vacancy BaTiO_(3) photothermal therapy photodynamic therapy PEROXIDASE
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