Transmission of Carbapenem Resistance Between Human and Animal NDM-Positive Escherichia coli Strains

查看全文 作　　者：Yingbo [1,2]Shen;Fupin [3]Hu;Yongqiang [4]Wang;Dandan [3]Yin;Lu [1]Yang;Yiqiang [5]Chen;Chunyan [1]Xu;Jiyun [1]Li;Junyao [1]Jiang;Xueyang [1]Wang;Yulin [1]Fu;Dongyan [1]Shao;Dejun [1]Liu;Tengfei [1]Ma;Chang [6]Cai;Zhangqi [1]Shen;Shaolin [1]Wang;Juan [7]Li;Rong [8]Zhang;Yuebin [9]Ke;Congming [1]Wu;Jianzhong [1]Shen;Timothy [10]R.Walsh;Yang [1]Wang

机构地区：[1]Beijing Key Laboratory of Detection Technology for Animal-Derived Food Safety,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;[2]CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;[3]Institute of Antibiotics&Key Laboratory of Clinical Pharmacology of Antibiotics(MoH),Huashan Hospital,Fudan University,Shanghai 200040,China;[4]Department of Preventive Veterinary Medicine,College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;[5]State Key Laboratory of Animal Nutrition,College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;[6]College of Animal Science and Technology,College of Veterinary Medicine,Zhejiang A and F University,Hangzhou 311300,China;[7]State Key Laboratory for Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention(CDC),Beijing 102206,China;[8]The Second Affiliated Hospital of Zhejiang University,Zhejiang University,Hangzhou 310009,China;[9]Key Laboratory of Genetics&Molecular Medicine of Shenzhen,Shenzhen Center for Disease Control and Prevention,Shenzhen 518055,China;[10]Department of Zoology,University of Oxford,Oxford OX13SZ,UK

出　　处：《Engineering》索引2022年第8卷第8期,共10页

基　　金：supported in part by the grants from National Natural Science Foundation of China(81991535,81861138051,and 81871690);UK MRC DETER-XDR-China-HUB(MR/S013768/1)。 摘　　要：Although carbapenem use is prohibited in animals in China,carbapenem-resistant Escherichia coli(CREC),especially New Delhi metallo-β-lactamase(NDM)-producing strains,are widely prevalent in foodproducing animals.At present,the impact of livestock-associated CREC strains on human populations at the national level is unknown.Here,we conduct a retrospective cross-sectional study to investigate the prevalence of CREC from clinical settings across 22 Chinese provinces or municipalities and analyze anthropogenic factors associated with their presence.We also ascertain the blaNDMand blaKPCabundance among pig and chicken farms and present a detailed genomic framework for CREC of animal and human origin.Overall,631/29799(2.1%)clinical Escherichia coli(E.coli)isolates were identified as CREC.Multivariable analysis revealed that being male,an age below 1,an age between 13 and 18,provinces with greater chicken production,and provinces with higher pig production were associated with higher odds of CREC infection.In general,73.8%(n=45/61)of pig farms and 62.2%(n=28/45)of chicken farms had a blaNDMabundance of 1×10^(-5)to 1×10^(-3)and 1×10^(-3)to 1×10^(-2),respectively.Among all the Chinese NDM-positive E.coli(n=463)available at the National Center for Biotechnology Information(NCBI),the genomic analysis revealed that blaNDM-5and Inc X3 were the predominant carbapenemase gene-plasmid combination,while a highly homogeneous relationship between NDM-positive isolates from humans and animals was demonstrated at the plasmid and core genome levels.All the findings suggest frequent CREC transmission between humans and animals,indicating that further discussions on the use of antibiotics in animals and humans are needed,both in China and across the globe. 关键词：Carbapenem resistance Escherichia coli blaNDM-5 One Health Antimicrobial resistance transmission

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Transmission of Carbapenem Resistance Between Human and Animal NDM-Positive Escherichia coli Strains

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