Clinical features of 162 fatal cases of COVID-19:a multi-center retrospective study

查看全文 作　　者：Xianlong [1]Zhou;Guoyong [2]Ding;Qing [3]Fang;Jun [4]Guo;Luyu [5]Yang;Ping [2]Wang;Shou-Zhi [5]Fu;Ang [1]Li;Jian [1]Xia;Jiangtao [1]Yu;Jianyou [6]Xia;Min [4]Ma;Zhuanzhuan [4]Hu;Lei [4]Huang;Ruining [1]Liu;Cheng [1]Jiang;Shaoping [1]Li;Mingxia [7]Yu;Xizhu [2]Xu;Yan [1,8]Zhao;Quan [9]Hu;Weijia [2]Xing;Zhigang [1,8]Zhao

机构地区：[1]Emergency Center,Zhongnan Hospital of Wuhan University,Wuhan,Hubei,China;[2]School of Public Health,Shandong First Medical University and Shandong Academy of Medical Sciences,Tai’an,Shandong,China;[3]Emergency Department,General Hospital of Central Theater Command of PLA,Wuhan,Hubei,China;[4]Intensive Care Unit,Huazhong University of Science and Technology Union Jiangbei Hospital,Wuhan,Hubei,China;[5]Intensive Care Unit,Wuhan Third Hospital,Wuhan,Hubei,China;[6]Department of Urology,General Hospital of Central Theater Command of PLA,Wuhan,Hubei,China;[7]Department of Clinical Laboratory,Zhongnan Hospital of Wuhan University,Wuhan,Hubei,China;[8]Hubei Clinical Research Center for Emergency and Resuscitation,Zhongnan Hospital of Wuhan University,Wuhan,Hubei,China;[9]Intensive Care Unit,The First People’s Hospital of Jiangxia District,Wuhan,Hubei,China

出　　处：《Emergency and Critical Care Medicine》索引2022年第2卷第3期,共7页

基　　金：supported by the National Natural Science Foundation of China(81900097,81903401);the Emergency Response Project of Hubei Science and Technology Department(2020FCA023);the Young Taishan Scholars Program of Shandong Province of China(tsqn20161046);the Shandong Province Higher Educational Young and Innovation Technology Supporting Program(2019KJL004);the Academic Promotion Program of Shandong First Medical University(2019RC010);the Emergency Diagnostic and Therapeutic Center of Central China. 摘　　要：Background:The coronavirus disease 2019(COVID-19)has affected approximately 2 million individuals worldwide;however,data regarding fatal cases have been limited.Objective:To report the clinical features of 162 fatal cases of COVID-19 from 5 hospitals in Wuhan between December 30,2019 and March 12,2020.Methods:The demographic data,signs and symptoms,clinical course,comorbidities,laboratory findings,computed tomographic(CT)scans,treatments,and complications of the patients with fatal cases were retrieved from electronic medical records.Results:The median patient age was 69.5(interquartile range:63.0–77.25)years,and 80%of the patients were over 61 years.A total of 112(69.1%)patients were men.Hypertension(45.1%)was the most common comorbidity,while 59(36.4%)patients had no comorbidity.At admission,131(81.9%)patients had severe or critical COVID-19,whereas 39(18.1%)patients with hypertension or chronic lung disease had moderate COVID-19.In total,126(77.8%)patients received antiviral treatment,while 132(81.5%)patients received glucocorticoid treatment.A total of 116(71.6%)patients were admitted to the intensive care unit(ICU),and 137(85.1%)patients received mechanical ventilation.Most patients received mechanical ventilation before ICU admission.Approximately 93.2%of the patients developed respiratory failure or acute respiratory distress syndrome.There were no significant differences in the inhospital survival time among the hospitals(P=0.14).Conclusion:Young patients with moderate COVID-19 without comorbidity at admission could also develop fatal outcomes.The in-hospital survival time of the fatal cases was similar among the hospitals of different levels in Wuhan. 关键词：Clinical features Coronavirus disease 2019 Fatal cases Survival time

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Clinical features of 162 fatal cases of COVID-19:a multi-center retrospective study

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