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High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence

查看全文 作　　者：Essa A [1,2]Mohamed;Nasra H [1,3]Giama;Abubaker O [4]Abdalla;Hassan M [1,5]Shaleh;Abdul M [1]Oseini;Hamdi A [1]Ali;Fowsiyo [1]Ahmed;Wesam [6]Taha;Hager Ahmed [1,7]Mohammed;Jessica [1]Cvinar;Ibrahim A [5]Waaeys;Hawa [1]Ali;Loretta K [1]Allotey;Abdiwahab O [5]Ali;Safra A [5]Mohamed;William S [1,8]Harmsen;Eimad M [1]Ahmmad;Numra A [1]Bajwa;Mohamud D [9]Afgarshe;Abdirashid M [1,10]Shire;Joyce E Balls-[2,11,12]Berry;Lewis R [1]Roberts 高影响力作者 机构地区：[1]Division of Gastroenterology and Hepatology,Mayo Clinic,Rochester,MN 55905,United States;[2]Center for Clinical and Translational Science,Mayo Clinic,Rochester,MN 55905,United States;[3]School of Nursing,University of Minnesota,Minneapolis,MN 55455,United States;[4]Division of Digestive Diseases,Emory School of Medicine,Atlanta,GA 30322,United States;[5]Department of Laboratory Medicine and Pathology,Mayo Clinic,Rochester,MN 55905,United States;[6]Department of Internal Medicine,NewYork-Presbyterian Queens,Flushing,NY 11355,United States;[7]Department of Pediatrics,University of Nevada Las Vegas,Las Vegas,NV 89154,United States;[8]Department of Quantitative Health Sciences,Mayo Clinic,Rochester,MN 55905,United States;[9]Department of Medicine,Gargar Urgent Care and Clinic,Minneapolis,MN 55406,United States;[10]Office of the Director,Shire Scientific,Minneapolis,MN 55405,United States;[11]Department of Neurology,Washington University School of Medicine in St Louis,St Louis,MO 63130,United States;[12]Knight Alzheimer Disease Research Center,Washington University School of Medicine,St Louis,MO 63130,United States高影响力机构 出　　处：《World Journal of Gastroenterology》索引2022年第28卷第35期,共13页高影响力期刊 基　　金：Supported by the Mayo Clinic Center for Clinical and Translational Science from the National Center for Advancing Translational Sciences (5UL1TR000135-10);the Mayo Clinic Hepatobiliary SPORE from the National Cancer Institute (5P50CA210964-04);the Mayo Clinic Center for Cell Signaling in Gastroenterology (5P30DK084567-14);Gilead Sciences,Inc.(IN-US-174-0230) 摘　　要：BACKGROUND Chronic hepatitis B virus(HBV)and hepatitis C virus(HCV)infections are known risk factors for liver disease,cirrhosis and hepatocellular carcinoma(HCC).There is substantial global variation in HBV and HCV prevalence resulting in variations in cirrhosis and HCC.We previously reported high prevalence of HBV and HCV infections in Somali immigrants seen at an academic medical center in Minnesota.AIM To determine the prevalence of chronic viral hepatitis in Somali immigrants in Minnesota through a community-based screening program.METHODS We conducted a prospective community-based participatory research study in the Somali community in Minnesota in partnership with community advisory boards,community clinics and local mosques between November 2010 and December 2015(data was analyzed in 2020).Serum was tested for hepatitis B surface antigen,hepatitis B core antibody,hepatitis B surface antibody and anti-HCV antibody.RESULTS Of 779 participants,15.4%tested positive for chronic HBV infection,50.2%for prior exposure to HBV and 7.6%for chronic HCV infection.Calculated age-adjusted frequencies in males and females for chronic HBV were 12.5%and 11.6%;for prior exposure to HBV were 44.8%and 41.3%;and for chronic HCV were 6.7%and 5.7%,respectively.Seven participants developed incident HCC during follow up.CONCLUSION Chronic HBV and HCV are major risk factors for liver disease and HCC among Somali immigrants,with prevalence of both infections substantially higher than in the general United States population.Community-based screening is essential for identifying and providing health education and linkage to care for diagnosed patients. 关 键 词：Viral hepatitis Liver disease Community engagement AFRICAN Immigrant health
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