Epigenetic regulation in cardiovascular disease:mechanisms and advances in clinical trials

查看全文 作　　者：Yuncong [1]Shi;Huanji [1]Zhang;Suli [2]Huang;Li [1]Yin;Feng [1]Wang;Pei [3]Luo;Hui [1]Huang

机构地区：[1]The Eighth Affiliated Hospital,Sun Yat-sen University,No.3025,Shennan Middle Rd,Futian District,518033 Shenzhen,China;[2]Shenzhen Center for Disease Control and Prevention,518055 Shenzhen,China;[3]State Key Laboratory of Chinese Materia Medica Quality Research,Macao University of Science and Technology,999078 Macao,China

出　　处：《Signal Transduction and Targeted Therapy》索引2022年第7卷第7期,共28页

基　　金：support by the National Key Research and Development Program[2020YFC2004405];National Natural Science Foundation of China(NSFC)[82073408]to JC,NSFC[82061160372 and 81870506];project of traditional Chinese medicine in Guangdong province[20201062];Basic Research Project of Shenzhen Science and Technology Innovation Committee[JCYJ20180306174648342 and JCYJ20190808102005602];Futian District Public Health Scientific Research Project of Shenzhen[FTWS2019003];Shenzhen Key Medical Discipline Construction Fund[SZXK002];Guangdong Basic and Applied Basic Research Foundation 2021B1515120083]. 摘　　要：Epigenetics is closely related to cardiovascular diseases.Genome-wide linkage and association analyses and candidate gene approaches illustrate the multigenic complexity of cardiovascular disease.Several epigenetic mechanisms,such as DNA methylation,histone modification,and noncoding RNA,which are of importance for cardiovascular disease development and regression.Targeting epigenetic key enzymes,especially the DNA methyltransferases,histone methyltransferases,histone acetylases,histone deacetylases and their regulated target genes,could represent an attractive new route for the diagnosis and treatment of cardiovascular diseases.Herein,we summarize the knowledge on epigenetic history and essential regulatory mechanisms in cardiovascular diseases.Furthermore,we discuss the preclinical studies and drugs that are targeted these epigenetic key enzymes for cardiovascular diseases therapy.Finally,we conclude the clinical trials that are going to target some of these processes. 关键词：CARDIOVASCULAR CLINICAL DIAGNOSIS

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Epigenetic regulation in cardiovascular disease:mechanisms and advances in clinical trials

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