Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?

查看全文 作　　者：Zichen [1]Feng;Ning [1]An;Fangfang [1]Yu;Jun [2]Ma;Na [3]Li;Yuhui [1]Du;Meng [1]Guo;Kaihong [1]Xu;Xiangbo [1]Hou;Zhiyuan [1]Li;Guoyu [1]Zhou;Yue [1]Ba

机构地区：[1]Department of Occupational and Environmental Health,School of Public Health,Zhengzhou University,Zhengzhou,Henan 450001,China;[2]Department of Endemic Disease,Kaifeng Center for Disease Control and Prevention,Kaifeng,Henan 475004,China;[3]Dietary Center,Zhengzhou Health Vocational Cllege,Zhengzhou,Henan 450122,China

出　　处：《Chinese Medical Journal》索引2022年第15期,共9页

基　　金：National Natural Science Foundation of China(Nos. 81972981, 82003401, and 81673116);Key Projects of Colleges and Universities of Henan Education Department(21A330006)。 摘　　要：Background: Excessive exposure to fluoride can reduce intelligence. Methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 (MTHFD1) polymorphisms have important roles in neurodevelopment. However, the association ofMTHFD1 polymorphisms with children’s intelligence changes in endemic fluorosis areas has been rarely explored.Methods: A cross-sectional study was conducted in four randomly selected primary schools in Tongxu County, Henan Province, from April to May in 2017. A total of 694 children aged 8 to 12 years were included in the study with the recruitment by the cluster sampling method. Urinary fluoride (UF) and urinary creatinine were separately determined using the fluoride ion-selective electrode and creatinine assay kit. Children were classified as the high fluoride group and control group according to the median of urinary creatinine-adjusted urinary fluoride (UFCr) level. Four loci ofMTHFD1 were genotyped, and the Combined Raven’s Test was used to evaluate children’s intelligence quotient (IQ). Generalized linear model and multinomial logistic regression model were performed to analyze the associations between children’s UFCr level,MTHFD1 polymorphisms, and intelligence. The general linear model was used to explore the effects of gene-environment and gene-gene interaction on intelligence.Results: In the high fluoride group, children’s IQ scores decreased by 2.502 when the UFCr level increased by 1.0 mg/L (β= –2.502, 95% confidence interval [CI]: –4.411, –0.593), and the possibility for having 'excellent' intelligence decreased by 46.3% (odds ratio = 0.537, 95% CI: 0.290, 0.994). Children with the GG genotype showed increased IQ scores than those with the AA genotype of rs11627387 locus in the high fluoride group (P < 0.05). Interactions between fluoride exposure andMTHFD1 polymorphisms on intelligence were observed (Pinteraction < 0.05).Conclusion: Our findings suggest that excessive fluoride exposure may have adverse effects on children’s intelligence, and changes in children’s intelligence may be associated with the interaction between fluoride andMTHFD1 polymorphisms. 关键词：FLUORIDE INTELLIGENCE Interaction MTHFD1 gene

相关文献

参考文献（57）
引证文献（2）
耦合文献（20）

参考文献(57)

引证文献(2)

耦合文献(20)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?

参考文献(57)

引证文献(2)

耦合文献(20)

用户提示