Evaluation of proximal tubule functions in children with COVID‑19:a prospective analytical study

查看全文 作　　者：Fatma [1]Devrim;Elif [2]Böncüoğlu;Elif [2]Kıymet;[2]ŞahikaŞahinkaya;Ela [2]Cem;Mine [2]Düzgöl;Aybüke Akaslan [2]Kara;KamileÖtiken [2]Arıkan;[1]AslıKantar;Ebru [1]Yılmaz;Nida [1]Dinçel;Nuri [2]Bayram;İlker [2]Devrim 机构地区：[1]Department of Pediatric Nephrology,University of Health Sciences Dr.Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital,İzmir,Turkey;[2]Department of Pediatric Infectious Diseases,University of Health Sciences Dr.Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital,İzmir,Turkey 出　　处：《World Journal of Pediatrics》索引2022年第18卷第9期,共6页 摘　　要：Background There are limited numbers of studies focusing on renal efects of coronavirus disease 2019(COVID-19)infection and proximal tubular dysfunction in children with COVID-19 infections.The purpose of this study was to evaluate the functions of the proximal tubule in hospitalized children with confrmed acute COVID-19.Methods The children who were hospitalized for confrmed COVID-19 were included in this prospective descriptive analysis.The presence of at least two of the following four abnormalities was used to diagnose proximal tubule injury:abnormal tubular reabsorption of phosphate,normoglycemic glycosuria,hyperuricosuria,and proteinuria.Results A total of 115 patients were included in the study.About a third of the individuals had elevated blood creatinine levels or proteinuria.In addition,abnormal renal tubular phosphate loss measured by renal tubular phosphate loss was found in 10(8.7%)patients,as was hyperuricosuria in 28.6%.As a result,total proximal tubular dysfunction was found in 24(20.9%)patients.Conclusions One in every fve children with acute COVID-19 infections had proximal tubular dysfunction,according to our data.Although,the rate of proximal tubular dysfunction was lower than in adults,it should be noted.The recovery of proximal tubular function in children with COVID-19 should be followed. 关 键 词：Coronavirus disease 2019(COVID-19) PROTEINURIA Proximal tubular dysfunction Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Tubular reabsorption of phosphate