Engineering multifunctional bioadhesive powders through dynamic metal-ligand coordination

查看全文 作　　者：Junchang [1]Guo;Yue [2]Hou;Liansong [3]Ye;Junnan [1]Chen;Hong [1]Wang;Li [4]Yang;Jinbo [2]Jiang;Qiangqiang [2]Sun;Chaoming [2]Xie;Bing [3]Hu;Jiaxi [1]Cui;Xu [1]Deng 机构地区：[1]Institute of Fundamental and Frontier Sciences,University of Electronic Science and Technology of China,Chengdu 610054,China;[2]Key Lab of Advanced Technologies of Materials,Ministry of Education,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China;[3]West China Hospitcal,Sichuan University,Chengdu 610041,China;[4]Institute for Advanced Study,Chengdu University,Chengdu 610106,China 出　　处：《Science China Chemistry》索引2022年第65卷第11期,共14页 基　　金：funding support by the National Natural Science Foundation of China(22072014);the Fundamental Research Funds for the Central Universities(ZYGX2019J119);Chengdu Science and Technology Bureau(2021-GH02-00105-HZ);Shenzhen Science and Technology Program(JCYJ20210324142210027);the Central Government Funds of Guiding Local Scientific and Technological Development for Sichuan Province(2021ZYD0046);Sichuan Outstanding Young Scholars Foundation(21JCQN0235)。 摘　　要：Bioadhesive gels with robust adhesion on wet and irregular tissue surfaces are desirable for clinical applications.Assembly of bioadhesive powders is an effective strategy for obtaining gels that adhere to wet and irregular tissue surfaces by absorbing interfacial water.However,current bioadhesive powders lack positive biological functions and are prone to postoperative adhesion.Here,we present a powder strategy based on metal-ligand coordination to create a series of bioadhesive polyacrylic acid(PAA)gels.In the gel network,metal ions(M^(n+))are used to coordinate with the carboxy ligands of PAA to form dynamic noncovalent crosslinks.The powders can absorb interfacial water and assemble into gels on wet and irregular tissue surfaces within a few seconds,forming an initial adhesion layer by electrostatic interactions.Furthermore,the polymers can diffuse into the tissue matrix,and metal-ligand coordination is reconstructed to enhance the adhesion.Moreover,with a cationic shield layer,the bioadhesive powders can effectively avoid postoperative adhesion.Importantly,M^(n+) ions endow the gel with customized biological functions.We demonstrate that the hemostatic,antibacterial,peroxidase-like catalytic,and photodetachment abilities of the gels by incorporating different M^(n+) ions.These advantages make the bioadhesive powder a promising platform for diverse tissue repair applications. 关 键 词：bioadhesive powders adhesive gel water-triggered gelation metal-ligand coordination functional gel