The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis

查看全文 作　　者：Silvia [1]Crespo;Marcus [1]Kind;Alexandre [1]Arcaro

机构地区：[1]Division of Pediatric Hematology/Oncology,Bern University Hospital,CH-3008 Bern,Switzerland

出　　处：《Journal of Cancer Metastasis and Treatment》索引2016年第2卷第1期,共10页

基　　金：supported by grants from the European Union FP7(ASSET,project number:259348 and LUNGTARGET,project number:259770);the Swiss National Science Foundation(Grant 31003A 146464)。 摘　　要：The PI3K/AKT/mTOR(PAM)pathway is involved in a variety of cellular functions and often contributes to oncogenesis and cancer progression.It has been recognized that this pathway is frequently activated in the most common central nervous system cancers of adults and children,malignant gliomas and medulloblastomas(MB).In these tumors,the PAM network controls key functions necessary for cell invasion and metastasis,such as cell motility.This review summarizes the current knowledge about the role of PAM signaling in cell invasion and metastasis in gliomas and MB.Current approaches to inhibit cell invasion and metastasis by targeting the PAM pathway will also be discussed. 关键词：PI3K/AKT/mTOR pathway GLIOBLASTOMA MEDULLOBLASTOMA METASTASIS

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The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis

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