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Steroid receptor coactivator-1:The central intermediator linking multiple signals and functions in the brain and spinal cord

查看全文 作　　者：Zhaoyou [1]Meng;Xiaoya [2]Wang;Dongmei [3]Zhang;Zhen [1]Lan;Xiaoxia [1,4]Cai;Chen [5]Bian;Jiqiang [1]Zhang 高影响力作者 机构地区：[1]Department of Neurobiology,Army Medical University,Chongqing 400038,PR China;[2]Department of Neurosurgery,Nanchong Central Hospital,the Second Clinical Medical College,North Sichuan Medical College,Nanchong,Sichuan 637000,PR China;[3]Department of Dermatology,Southwest Hospital,Army Medical University,Chongqing 400038,PR China;[4]School of Life Sciences,Southwest University,Chongqing 400715,PR China;[5]School of Psychology,Amy Medical University,Chongqing 400038,PR China高影响力机构 出　　处：《Genes & Diseases》索引2022年第9卷第5期,共9页高影响力期刊 基　　金：supported by the National Science Foundation of China(NSFC,No.81571059);the Postdoctoral Research Foundation of China(No.2019M653976);Natural Science Foundation of Chongqing,China(No.cstc2019jcyj-msxmX0255). 摘　　要：The effects of steroid hormones are believed to be mediated by their nuclear receptors(NRs).The p160 coactivator family,including steroid receptor coactivator-1(SRC-1),2 and 3,has been shown to physically interact with NRs to enhance their transactivational activities.Among which SRC-1 has been predominantly localized in the central nervous system including brain and spinal cord.It is not only localized in neurons but also detectable in neuroglial cells(mainly localized in the nuclei but also detectable in the extra-nuclear components).Although the expression of SRC-1 is regulated by many steroids,it is also regulated by some non-steroidal factors such as injury,sound and light.Functionally,SRC-1 has been implied in normal function such as development and ageing,learning and memory,central regulation on reproductive behaviors,motor and food intake.Pathologically,SRC-1 may play a role in the regulation of neuropsychiatric disorders(including stress,depression,anxiety,and autism spectrum disorder),metabolite homeostasis and obesity as well as tumorigenesis.Under most conditions,the related mechanisms are far from elucidation;although it may regulate spatial memory through Rictor/mTORC2-actin polymerization related synaptic plasticity.Several inhibitors and stimulator of SRC-1 have shown anti-cancer potentials,but whether these small molecules could be used to modulate ageing and central disorder related neuropathology remain unclear.Therefore,to elucidate when and how SRC-1 is turned on and off under different stimuli is very interesting and great challenge for neuroscientists. 关 键 词：Cognition NEUROPATHOLOGY NEUROPSYCHIATRY STEROID Steroid receptor coactivator-1 Synaptic plasticity
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