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Sonosensitized Aggregation-Induced Emission Dots with Capacities of Immunogenic Cell Death Induction and Multivalent Blocking of Programmed Cell Death-Ligand 1 for Amplified Antitumor Immunotherapy

查看全文 作　　者：Shaorui [1]Jia;Zhiyuan [1]Gao;Zelin [1]Wu;Heqi [1]Gao;He [2]Wang;Hanlin [1]Ou;Dan [1]Ding 高影响力作者 机构地区：[1]Key Laboratory of Bioactive Materials Ministry of Education,College of Life Sciences,State Key Laboratory of Medicinal Chemical Biology,Nankai University,Tianjin 300071;[2]Department of Urology,First Affiliated Hospital of Soochow University,Suzhou 215006高影响力机构 出　　处：《CCS Chemistry》索引2022年第4卷第2期,共14页高影响力期刊 基　　金：supported by the National Key R&D Program of China(Intergovernmental Cooperation Project,no.2017YFE0132200);the NSFC(nos.5191160730,51873092,and 81921004);the Tianjin Science Fund for Distinguished Young Scholars(no.19JCQJC61200). 摘　　要：The combination of immunogenic cell death(ICD)induction and immune checkpoint blockade has emerged as a major direction of cancer immunotherapy.Among currently available ICD inducers,sonosensitizers that produce reactive oxygen species(ROS)under an external trigger to evoke ICD of tumor cells have shown great promise.However,a highly efficient sonosensitizer-based ICD inducer with an aggregationinduced emission(AIE)characteristic has yet to be developed.Herein,a novel AIE sonosensitizer with a twisted molecular structure,very small energy gap between the singlet and triplet excited states(ΔE_(ST)),and efficient ROS generation ability,which can serve as an effective ICD inducer,is reported for sonodynamic processes in cancer immunotherapy.Furthermore,an AIE sonosensitizer-based nanosystem with surface modification of anti-PD-L1 peptide is constructed for boosting antitumor immunotherapy.In this system,AIE sonosensitizer-mediated sonodynamic therapy can successfully convert a hypoimmunogenic cold tumor to a hot one and further facilitate the multivalent blocking of programed death ligand(PD-L1)by anti-PD-L1 peptides.Such an advanced nanosystem could effectively initiate the activation of antitumoral immune reactions and modulation of an immunosuppressive microenvironment,contributing to systemic antitumor effects to further inhibit the growth of distant tumors. 关 键 词：aggregation-induced emission sonodynamic therapy immunogenic cell death PD-L1 antitumor immunotherapy
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