Hypoxia-induced reactive oxygen species in organ and tissue fibrosis

查看全文 作　　者：LINSHEN [1]XIE;QIAOLAN [1]WANG;JINGXUAN [1]MA;YE [2]ZENG

机构地区：[1]West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,610041,China;[2]Institute of Biomedical Engineering,West China School of Basic Medical Sciences and Forensic Medicine,Sichuan University,Chengdu,610041,China

出　　处：《BIOCELL》索引2023年第47卷第2期,共7页

基　　金：supported by the Science and Technology Department of Sichuan Province(No.2021YFS0182);Science and Technology Department of Tibet(No.XZ202201ZY0033G);Sichuan Provincial Administration of Traditional Chinese Medicine(No.2021MS088). 摘　　要：Fibrosis is the end-stage change of damaged tissues in various human diseases,which can lead to permanent scarring or organ malfunction.Hypoxia leads to oxidative stress,mitochondrial dysfunction,and inflammation in dysfunctional organs and tissues.Oxidative stress resulting from the overproduction of reactive oxygen species plays a central role in the fibrosis of injured organs.This review addresses the updated knowledge of the relationship between hypoxia and tissue fibrosis mediated by the reactive oxygen species pathway.Moreover,novel anti-fibrotic strategies are discussed,which may suppress reactive oxygen species and organ fibrosis. 关键词：FIBROSIS Oxidative stress HYPOXIA

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Hypoxia-induced reactive oxygen species in organ and tissue fibrosis

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