Continued evolution of the Eurasian avian-like H1N1 swine influenza viruses in China

查看全文 作　　者：Fei [1]Meng;Yan [1]Chen;Zuchen [1]Song;Qiu [1]Zhong;Yijie [1]Zhang;Chuanling [1]Qiao;Cheng [1]Yan;Huihui [1]Kong;Liling [1]Liu;Chengjun [1]Li;Huanliang [1]Yang;Hualan [1]Chen

机构地区：[1]State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150069,China

出　　处：《Science China(Life Sciences)》索引2023年第66卷第2期,共14页

基　　金：supported by the National Key Research and Development Program of China(2021YFD1800200,2021YFC2301700)。 摘　　要：Animal influenza viruses continue to pose a threat to human public health. The Eurasian avian-like H1N1(EA H1N1) viruses are widespread in pigs throughout Europe and China and have caused human infections in several countries, indicating their pandemic potential. To carefully monitor the evolution of the EA H1N1 viruses in nature, we collected nasal swabs from 103,110pigs in 22 provinces in China between October 2013 and December 2019, and isolated 855 EA H1N1 viruses. Genomic analysis of 319 representative viruses revealed that these EA H1N1 viruses formed eight different genotypes through reassortment with viruses of other lineages circulating in humans and pigs, and two of these genotypes(G4 and G5) were widely distributed in pigs.Animal studies indicated that some strains have become highly pathogenic in mice and highly transmissible in ferrets via respiratory droplets. Moreover, two-thirds of the EA H1N1 viruses reacted poorly with ferret serum antibodies induced by the currently used H1N1 human influenza vaccine, suggesting that existing immunity may not prevent the transmission of the EA H1N1 viruses in humans. Our study reveals the evolution and pandemic potential of EA H1N1 viruses and provides important insights for future pandemic preparedness. 关键词：H1N1 INFLUENZA IMMUNITY

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Continued evolution of the Eurasian avian-like H1N1 swine influenza viruses in China

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