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The MEKK1-MKK1/2-MPK4 cascade phosphorylates and stabilizes STOP1 to confer aluminum resistance in Arabidopsis

查看全文 作　　者：Fanglin [1,2]Zhou;Somesh [1]Singh;Jie [1]Zhang;Qiu [1]Fang;Chongyang [1]Li;Jiawen [1]Wang;Chunzhao [1]Zhao;Pengcheng [1]Wang;Chao-Feng [1,2]Huang 高影响力作者 机构地区：[1]National Key Laboratory of Plant Molecular Genetics,Shanghai Center for Plant Stress Biology,CAS Center for Excellence in Molecular Plant Sciences,Shanghai Institute of Plant Physiology and Ecology,Chinese Academy of Sciences,Shanghai 200032,China;[2]University of the Chinese Academy of Sciences,Beijing 100049,Cnina高影响力机构 出　　处：《Molecular Plant》索引2023年第16卷第2期,共17页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(grant nos.32170261 and 31870223 to C.-F.H.);the National Key Laboratory of Plant Molecular Genetics. 摘　　要：Aluminum(Al)toxicity can seriously restrict crop production on acidic soils,which comprise 40%of the world’s potentially arable land.The zinc finger transcription factor STOP1 has a conserved and essential function in mediating plant Al resistance.Al stress induces STOP1 accumulation via post-transcriptional regulatory mechanisms.However,the upstream signaling pathway involved in Al-triggered STOP1 accumulation remains unclear.Here,we report that the MEKK1-MKK1/2-MPK4 cascade positively regulates STOP1 phosphorylation and stability.Mutations of MEKK1,MKK1/2,or MPK4 lead to decreased STOP1 stability and Al resistance.Al stress induces the kinase activity of MPK4,which interacts with and phosphorylates STOP1.The phosphorylation of STOP1 reduces its interaction with the F-box protein RAE1 that mediates STOP1 degradation,thereby leading to enhanced STOP1 stability and Al resistance.Taken together,our results suggest that the MEKK1-MKK1/2-MPK4 cascade is important for Al signaling and confers Al resistance through phosphorylation-mediated enhancement of STOP1 accumulation in Arabidopsis. 关 键 词：aluminum resistance Arabidopsis thaliana MAPK cascade MPK4 STOP1 phosphorylation STOP1 stability
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