维普中文期刊产品整合服务

TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma

查看全文 作　　者：Huigang [1,2,3,4]Li;Zuyuan [1,2,3,4]Lin;Jianyong [1,2,3,4]Zhuo;Modan [1,2,3,4]Yang;Wei [1,2,3,4]Shen;Zhihang [1,2,3,4]Hu;Yichen [1]Ding;Hao [1,2,3,4]Chen;Chiyu [1,2,3,4]He;Xinyu [1,2,3,4]Yang;Siyi [5]Dong;Xuyong [1,2,3,4]Wei;Beicheng [6]Sun;Shusen [4,5,7,8,9]Zheng;Ren [10]Lang;Di [1,2,3,4]Lu;Xiao [1,3,4,5]Xu 高影响力作者 机构地区：[1]Zhejiang University School of Medicine,Hangzhou 310058,China;[2]Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province,Department of Hepatobiliary and Pancreatic Surgery,Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Hangzhou 310006,China;[3]The Institute for Organ Repair and Regenerative Medicine of Hangzhou,Hangzhou 310006,China;[4]Institute of Organ Transplantation,Zhejiang University,Hangzhou 310003,China;[5]National Center for Healthcare Quality Management in Liver Transplant,Hangzhou 310003,China;[6]Department of Hepatobiliary Surgery,the Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China;[7]Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;[8]Department of Hepatobiliary and Pancreatic Surgery,Shulan(Hangzhou)Hospital,Hangzhou 311112,China;[9]NHC Key Laboratory of Combined Multi-organ Transplantation,Hangzhou 31003,China;[10]Department of Hepatobiliary Surgery,Beijing Chaoyang Hospital Affiliated to Capital Medical University,Beijing 100020,China高影响力机构 出　　处：《Chinese Journal of Cancer Research》索引2023年第35卷第1期,共15页高影响力期刊 基　　金：the National Key Research and Development Program of China(No.2021YFA1100500);the Major Research Plan of the National Natural Science Foundation of China(No.92159202);the Key Research&Development Plan of Zhejiang Province(No.2019C03050),the Key Research&Development Plan of Zhejiang Province(No.2021C03118);National S&T Major Project(No.2017ZX10203205);the Health Science&Technology Plan of Zhejiang Province(No.2022RC060)。 摘　　要：Objective:Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma(HCC).The precise prediction of post-transplant lung metastasis in the early phase is of great value.Methods:The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways.We enrolled 241 HCC patients who underwent liver transplantation from three centers.Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor(TNF),tumor necrosis factor receptor 1(TNFR1),and TNFR2,particularly for post-transplant lung metastasis.Results:Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC.The expression of TNF was degraded in comparison to that in para-tumor tissues(P<0.001).The expression of key receptors in the TNF-dependent signaling pathway,TNFR1 and TNFR2,was higher in HCC tissues than in para-tumor tissues(P<0.001).TNF and TNFR1 showed no relationship with patients’outcomes,whereas elevated TNFR2 in tumor tissue was significantly associated with worse overall survival(OS)and increased recurrence risk(5-year OS rate:31.9%vs.62.5%,P<0.001).Notably,elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis(hazard ratio:1.146;P<0.001).Cox regression analysis revealed that TNFR2,Hangzhou criteria,age,and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis,and a novel nomogram was established accordingly.The nomogram achieved excellent prognostic efficiency(area under time-dependent receiver operating characteristic=0.755,concordance-index=0.779)and was superior to conventional models,such as the Milan criteria.Conclusions:TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC.A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC. 关 键 词：Lung metastasis hepatocellular carcinoma liver transplantation NOMOGRAM
相关文献

参考文献(44)

引证文献(3)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费