Mosaic theory revised:inflammation and salt play central roles in arterial hypertension

查看全文 作　　者：Felicitas [1]E.Hengel;Jean-Pierre [2]Benitah;Ulrich [1]O.Wenzel

机构地区：[1]Ⅲ.Department of Medicine,University Hospital Hamburg-Eppendorf,Hamburg,Germany;[2]Inserm UMR-S 1180,Faculty of Pharmacy,University Paris Saclay,Gif-sur-Yvette,France

出　　处：《Cellular & Molecular Immunology》索引2022年第19卷第5期,共16页

基　　金：supported by the German Research Foundation and the ADMIRE network. 摘　　要：The mosaic theory of hypertension was advocated by Irvine Page~80 years ago and suggested that hypertension resulted from the close interactions of different causes.Increasing evidence indicates that hypertension and hypertensive end-organ damage are not only mediated by the proposed mechanisms that result in hemodynamic injury.Inflammation plays an important role in the pathophysiology and contributes to the deleterious consequences of arterial hypertension.Sodium intake is indispensable for normal body function but can be detrimental when it exceeds dietary requirements.Recent data show that sodium levels also modulate the function of monocytes/macrophages,dendritic cells,and different T-cell subsets.Some of these effects are mediated by changes in the microbiome and metabolome due to high-salt intake.The purpose of this review is to propose a revised and extended version of the mosaic theory by summarizing and integrating recent advances in salt,immunity,and hypertension research.Salt and inflammation are placed in the middle of the mosaic because both factors influence each of the remaining pieces. 关键词：Arterial hypertension SALT innate and adaptive immunity renin angiotensin aldosterone system mineralocorticoid receptor angiotensinⅡreceptor

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Mosaic theory revised:inflammation and salt play central roles in arterial hypertension

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