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Autoimmune liver diseases and SARS-CoV-2

查看全文 作　　者：Costantino [1]Sgamato;Alba [1]Rocco;Debora [1]Compare;Stefano [1]Minieri;Stefano Andrea [1]Marchitto;Simone [2]Maurea;Gerardo [1]Nardone 高影响力作者 机构地区：[1]Department of Clinical Medicine and Surgery,University of Naples Federico Ⅱ,Naples 80131,Italy;[2]Department of Advanced Biomedical Sciences,University of Naples Federico Ⅱ,Naples 80131,Italy高影响力机构 出　　处：《World Journal of Gastroenterology》索引2023年第29卷第12期,共14页高影响力期刊 摘　　要：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing coronavirus disease 2019(COVID-19),can trigger autoimmunity in genetically predisposed individuals through hyperstimulation of immune response and molecular mimicry.Here we summarise the current knowledge about autoimmune liver diseases(AILDs)and SARS-CoV-2,focusing on:(1)The risk of SARS-CoV-2 infection and the course of COVID-19 in patients affected by AILDs;(2)the role of SARS-CoV-2 in inducing liver damage and triggering AILDs;and(3)the ability of vaccines against SARS-CoV-2 to induce autoimmune responses in the liver.Data derived from the literature suggest that patients with AILDs do not carry an increased risk of SARS-Cov-2 infection but may develop a more severe course of COVID-19 if on treatment with steroids or thiopurine.Although SARSCoV-2 infection can lead to the development of several autoimmune diseases,few reports correlate it to the appearance of de novo manifestation of immunemediated liver diseases such as autoimmune hepatitis(AIH),primary biliary cholangitis(PBC)or AIH/PBC overlap syndrome.Different case series of an AIHlike syndrome with a good prognosis after SARS-CoV-2 vaccination have been described.Although the causal link between SARS-CoV-2 vaccines and AIH cannot be definitively established,these reports suggest that this association could be more than coincidental. 关 键 词：Autoimmune liver disease SARS-CoV-2 COVID-19 COVID-19 vaccine Autoimmune hepatitis
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