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Maackiain inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by inhibiting the MAPK/Ras signaling pathway

查看全文 作　　者：JIANG [1,2,3]Xing;YANG [2]Xiaonan;SHI [1,2]Yanxia;LONG [1,2]Yan;SU [2,4]Wenqing;HE [2,5]Wendong;WEI [2]Kunhua;MIAO [1,2]Jianhua 高影响力作者 机构地区：[1]College of Pharmacy,Guangxi Medical University,Nanning 530021,China;[2]Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement/Guangxi Engineering Research Center of TCM Resource Intelligent Creation,Guangxi Botanical Garden of Medicinal Plants,Nanning 530023,China;[3]The Second Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang 421001,China;[4]College of Pharmacy,Youjiang Medical University for Nationalities,Baise 533000,China;[5]Department of Pharmacy,Guangxi Medical University Affiliated Tumor Hospital,Nanning 530021,China高影响力机构 出　　处：《Chinese Journal of Natural Medicines》索引2023年第21卷第3期,共12页高影响力期刊 基　　金：the Independent Subject of Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement(No.KL2022ZZ01);Guangxi Innovation-Driven Development Project(No.GuiKe AA18242040);the National Key R&D Program of China(Nos.2019YFC1711000 and 2019YFC1711008);the Innovation Team Project of Guangxi Botanical Garden of Medicinal Plant(No.GuiYaoChuang2019002);the Innovation and Demonstration of Guangxi Academician Workstation(No.2021AV07007);Government Guided Local Science and Technology Development Project(No.GuiKeZY 20198018). 摘　　要：Nasopharyngeal carcinoma(NPC)is the third most common malignancy with a high recurrence and metastasis rate in South China.Natural compounds extracted from traditional Chinese herbal medicines have been developed and utilized for the treatment of a variety of cancers with modest properties and slight side effects.Maackiain(MA)is a type of flavonoid that was first isolated from leguminous plants,and it has been reported to relieve various nervous system disorders and exert anti-allergic as well as antiinflammatory effects.In this study,we demonstrated that MA inhibited proliferation,arrested cell cycle and induced apoptosis in nasopharyngeal carcinoma CNE1 and CNE2 cells in vitro and in vivo.The expression of the related proteins associated with these processes were consistent with the above effects.Moreover,transcriptome sequencing and subsequent Western blot experiments revealed that inhibition of the MAPK/Ras pathway may be responsible to the anti-tumor effect of MA on NPC cells.Therefore,the effects of MA and an activator of this pathway,tertiary butylhydroquinone(TBHQ),alone or combination,were investigated.The results showed TBHQ neutralized the inhibitory effects of MA.These data suggest that MA exerts its anti-tumor effect by inhibiting the MAPK/Ras signaling pathway and it has the potential to become a treatment for patients with NPC. 关 键 词：Nasopharyngeal carcinoma Maackiain PROLIFERATION Cell cycle Apoptosis Transcriptome sequencing MAPK/Ras signaling pathway
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