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A shear-thinning,ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis

查看全文 作　　者：Yibo [1,2]Ying;Zhiyang [1,2]Huang;Yurong [1,2]Tu;Qiuji [1,2]Wu;Zhaoyu [6]Li;Yifan [1,2]Zhang;Huilei [1,2]Yu;Annian [1,2]Zeng;Hanzhi [1,2]Huang;Jiahui [1,2]Ye;Weiyang [1,2,3]Ying;Min [1,2]Chen;Zhiyi [1,2]Feng;Ziyue [1,2]Xiang;Qingsong [4,5]Ye;Sipin [1,2]Zhu;Zhouguang [1,2]Wang 高影响力作者 机构地区：[1]School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,Zhejiang,325000,China;[2]Department of Orthopaedics,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China;[3]Department of Pain Medicine,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,325000,Zhejiang,China;[4]Center of Regenerative Medicine,Renmin Hospital of Wuhan University,Wuhan,460030,Hubei,China;[5]Massachusetts General Hospital,Harvard University,Boston,02114,USA;[6]Department of Overseas Education College,Jimei University,Xiamen,Fujian,China高影响力机构 出　　处：《Bioactive Materials》索引2023年第4期,共17页高影响力期刊 基　　金：This study was partly funded by grants from the National Natural Science Funding of China(82172424,82271629);Outstanding Youth Fund of Zhejiang Province(LR22H060002);Zhejiang Medical and Health Science and Technology Plan Project(2022RC210,2021KY212);Wenzhou Basic Science Research Plan Project(Y20210045);CAMS Innovation Fund for Medical Sciences(2019-I2M-5-028). 摘　　要：Spinal cord injury(SCI)is a serious clinical disease.Due to the deformability and fragility of the spinal cord,overly rigid hydrogels cannot be used to treat SCI.Hence,we used TPA and Laponite to develop a hydrogel with shear-thinning ability.This hydrogel exhibits good deformation,allowing it to match the physical properties of the spinal cord;additionally,this hydrogel scavenges ROS well,allowing it to inhibit the lipid peroxidation caused by ferroptosis.According to the in vivo studies,the TPA@Laponite hydrogel could synergistically inhibit ferroptosis by improving vascular function and regulating iron metabolism.In addition,dental pulp stem cells(DPSCs)were introduced into the TPA@Laponite hydrogel to regulate the ratios of excitatory and inhibitory synapses.It was shown that this combination biomaterial effectively reduced muscle spasms and promoted recovery from SCI. 关 键 词：Shear-thinning hydrogel Dental pulp stem cells Ferroptosis ROS-Scavenging Synaptic regulation
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