维普中文期刊产品整合服务

Anti-oxidant anti-inflammatory and antibacterial tannin-crosslinked citrate-based mussel-inspired bioadhesives facilitate scarless wound healing

查看全文 作　　者：Keke [1]Wu;Meimei [1]Fu;Yitao [1]Zhao;Ethan [2]Gerhard;Yue [1]Li;Jian [2]Yang;Jinshan [1]Guo 高影响力作者 机构地区：[1]Department of Histology and Embryology,NMPA Key Laboratory for Safety Evaluation of Cosmetics,School of Basic Medical Sciences,Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases,The Third Affiliated Hospital of Southern Medical University,Southern Medical University,Guangzhou,China;[2]Department of Biomedical Engineering,Pennsylvania State University,University Park,PA,16802,USA高影响力机构 出　　处：《Bioactive Materials》索引2023年第2期,共18页高影响力期刊 基　　金：funded by the National Natural Science Foundation of China(NSFC,Grant No.U21A2099,82102545);the Chinese Postdoctoral Science Foundation(Grant No.2021M701627);the Guangdong Basic and Applied Basic Research Foundation(Grant No.2022A1515011982,2020A1515110062). 摘　　要：The revolutionary role of tissue adhesives in wound closure,tissue sealing,and bleeding control necessitates the development of multifunctional materials capable of effective and scarless healing.In contrast to the use of traditionally utilized toxic oxidative crosslinking initiators(exemplified by sodium periodate and silver nitrate),herein,the natural polyphenolic compound tannic acid(TA)was used to achieve near instantaneous(<25s),hydrogen bond mediated gelation of citrate-based mussel-inspired bioadhesives combining anti-oxidant,anti-inflammatory,and antimicrobial activities(3A-TCMBAs).The resulting materials were self-healing and possessed low swelling ratios(<60%)as well as considerable mechanical strength(up to~1.0 MPa),elasticity(elongation~2700%),and adhesion(up to 40 kPa).The 3A-TCMBAs showed strong in vitro and in vivo anti-oxidant ability,favorable cytocompatibility and cell migration,as well as photothermal antimicrobial activity against both Staphylococcus aureus and Escherichia coli(>90%bacterial death upon near-infrared(NIR)irradiation).In vivo evaluation in both an infected full-thickness skin wound model and a rat skin incision model demonstrated that 3A-TCMBAs+NIR treatment could promote wound closure and collagen deposition and improve the collagen Ⅰ/Ⅲ ratio on wound sites while simultaneously inhibiting the expression of pro-inflammatory cytokines.Further,phased angiogenesis was observed via promotion in the early wound closure phases followed by inhibition and triggering of degradation&remodeling of the extracellular matrix(ECM)in the late stage(supported by phased CD31(platelet endothelial cell adhesion molecule-1)PDGF(platelet-derived growth factor)and VEGF(vascular endothelial growth factor)expression as well as elevated matrix metalloprotein-9(MMP-9)expression on day 21),resulting in scarless wound healing.The significant convergence of material and bioactive properties elucidated above warrant further exploration of 3A-TCMBAs as a significant,new class of bioadhesive. 关 键 词：ANTI-OXIDANT Hydrogen bond crosslinking Phased angiogenesis Scarless wound healing Tannic acid
相关文献

参考文献(77)

引证文献(11)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费