Multilayered organic semiconductors for high performance optoelectronic stimulation of cells

查看全文 作　　者：Aleksandr [1,5]Markov;Alexander [1,2]Gerasimenko;Annie-Kermen [1]Boromangnaeva;Sofia [1]Shashova;Elena [1]Iusupovskaia;Ulyana [2,5]Kurilova;Vita [3]Nikitina;Irina [4]Suetina;Marina [4]Mezentseva;Mikhail [2,6]Savelyev;Peter [5,6,7]Timashev;Dmitry [1,2]Telyshev;Xing-Jie [6,8,9]Liang 机构地区：[1]Institute for Bionic Technologies and Engineering,I.M.Sechenov First Moscow State Medical University,Moscow 119991,Russia;[2]Institute of Biomedical Systems,National Research University of Electronic Technology,Zelenograd,Moscow 124498,Russia;[3]Chemistry Department,Lomonosov Moscow State University,Leninskie Gory,1/3,Moscow 119991,Russia;[4]Ivanovsky Institute of Virology,N.F.Gamaleya National Center of Epidemiology and Microbiology,Moscow 123098,Russia;[5]World-Class Research Center“Digital Biodesign and Personalized Healthcare”,I.M.Sechenov First Moscow State Medical University,Moscow 119991,Russia;[6]Laboratory of Clinical Smart Nanotechnologies,I.M.Sechenov First Moscow State Medical University,Moscow 119991,Russia;[7]Institute for Regenerative Medicine,I.M.Sechenov First Moscow State Medical University,Moscow 119991,Russia;[8]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China,Beijing 100190,China;[9]University of Chinese Academy of Sciences,Beijing 100049,China 出　　处：《Nano Research》索引2023年第16卷第4期,共8页 基　　金：funded by the Ministry of Science and Higher Education of the Russian Federation(No.075-15-2021-596). 摘　　要：The efficiency of devices for bioelectronic applications,including cell and tissue stimulation,is heavily dependent on the scale and the performance level.With miniaturization of stimulation electrodes,achieving a sufficiently high current pulse to elicit action potentials becomes an issue.Herein we report on our approach of vertically stacking organic p-n junctions to create highlyefficient multilayered organic semiconductor(MOS)photostimulation device.A tandem arrangement substantially increases the photovoltage and charge density without sacrificing lateral area,while not exceeding 200-500 nm of thickness.These devices generate 4 times higher voltages and at least double the charge densities over single p-n junction devices,which allow using lower light intensities for stimulation.MOS devices show an outstanding stability in the electrolyte that is extremely important for forthcoming in vivo experiments.Finally,we have validated MOS devices performance by photostimulating fibroblasts and neuroblasts,and found that using tandem devices leads to more effective action potential generation.As a result,we obtained up to 4 times enhanced effect in cell growth density using 3 p-n layered devices.These results corroborate the conclusion that MOS technology not only can achieve parity with state-of-the-art silicon devices,but also can exceed them in miniaturization and performance for biomedical applications. 关 键 词：BIOELECTRONICS organic semiconductors wireless stimulation FIBROBLASTS neuroblastoma cells