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Supramolecular liquid barrier for sulfur mustard utilizing host-guest complexation of pillar[5]arene with triethylene oxide substituents

查看全文 作　　者：Yahan [1]Zhang;Junyi [1,2]Chen;Longming [1]Chen;Liang [1]Zhao;Mengke [1]Ma;Xinbei [1]Du;Zhao [1]Meng;Han [1]Zhang;Zhibing [1]Zheng;Yongan [1]Wang;Chunju [2]Li;Qingbin [1]Meng 高影响力作者 机构地区：[1]State Key Laboratory of Toxicology and Medical Countermeasures,Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China;[2]Key Laboratory of Inorganic-Organic Hybrid Functional Material Chemistry,Ministry of Education,Tianjin Key Laboratory of Structure and Performance for Functional Molecules,College of Chemistry,Tianjin Normal University,Tianjin 300387,China高影响力机构 出　　处：《Chinese Chemical Letters》索引2023年第34卷第4期,共4页高影响力期刊 基　　金：financially supported by National Natural Science Foundation of China (Nos. 22171286, 21772118, 21971192);the Natural Science Foundation of Tianjin City (No. 20JCZDJC00200);the Special Fund of Military Medical Science (Nos. BWS16J007,AWS17J009)。 摘　　要：Sulfur mustard(SM) can be absorbed by skin quickly and cause serious system damage via reacting with nearly all cell constituents. Until now, there is still lack of effective antidotal therapy for SM and skin protection is highly important to defend SM. In this article, supramolecular liquid barrier based on pillar[5]arene with triethylene oxide substituents(EGP5) has been designed to impede the skin permeation of SM and further interaction with the skin tissue. EGP5 could encapsulate SM within its cavity, with a Kavalue of(5.10 ± 0.47) × 10^(2)L/mol. In vitro skin absorption test proved that EGP5 was capable to effectively prevent SM from penetrating through skin. This supramolecular liquid barrier was employed on rat models to systematically evaluate protective effect against SM intoxication. Pretreatment of EGP5could alleviate skin and system damage induced by SM and improve survival rate of poisoned rat models from 10% to 90%. Additionally, EGP5 served as protective materials could be highly reused after recycling several times. Overall, these findings have provided the first insight into the construction of convenient liquid material for SM protection. 关 键 词：Supramolecular barrier Host-guest complexation Liquid pillar[5]arene Sulfur mustard Skin protection
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