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Multimodal biofeedback for Parkinson’s disease motor and nonmotor symptoms

查看全文 作　　者：Zhongyan [1]Shi;Lei [2]Ding;Xingyu [1]Han;Bo [1]Jiang;Jiangtao [1]Zhang;Dingjie [1]Suo;Jinglong [3]Wu;Guangying [1]Pei;Boyan [4]Fang;Tianyi [1]Yan 高影响力作者 机构地区：[1]School of Life Science,Beijing Institute of Technology,Beijing 100081,China;[2]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Anesthesiology,Peking University Cancer Hospital and Institute,Beijing 100142,China;[3]School of Medical Technology,Beijing Institute of Technology,Beijing 100081,China;[4]Department of Neurology,Beijing Rehabilitation Hospital,Capital Medical University,Beijing 100081,China高影响力机构 出　　处：《Brain Science Advances》索引2023年第9卷第2期,共19页高影响力期刊 基　　金：This work was supported by the STI 2030-Major Projects(Grant No.2022ZD0208500);the National Natural Science Foundation of China(Grant Nos.U20A20191,82071912,12104049,82202291);the Key Research and Development Program(Grant No.2022YFC3602603);the Fundamental Research Funds for the Central Universities(Grant No.2021CX11011);the National Key Research and Development Program of China(Grant No.2020YFC2007305). 摘　　要：Parkinson’s disease(PD)is a neurodegenerative disordercharacterized by motor retardation,myotonia,quiescent tremor,and postural gait abnormality,as well as nonmotor symptoms such asanxiety and depression.Biofeedback improves motor and nonmotorfunctions of patients by regulating abnormal electroencephalogram(EEG),electrocardiogram(ECG),photoplethysmography(PPG),electromyography(EMG),respiration(RSP),or other physiologicalsignals.Given that multimodal signals are closely related to PDstates,the clinical effect of multimodal biofeedback on patientswith PD is worth exploring.Twenty-one patients with PD in Beijing Rehabilitation Hospital were enrolled and divided into threegroups:multimodal(EEG,ECG,PPG,and RSP feedback signal),EEG(EEG feedback signal),and sham(random feedback signal),and they received biofeedback training five times in two weeks.The combined clinical scale and multimodal signal analysis resultsrevealed that the EEG group significantly improved motor symptomsand increased Berg balance scale scores by regulatingβband activity;the multimodal group significantly improved nonmotorsymptoms and reduced Hamilton rating scale for depression scores by improvingθband activity.Our preliminary results revealed thatmultimodal biofeedback can improve the clinical symptoms of PD,but the regulation effect on motor symptoms is weaker than that ofEEG biofeedback. 关 键 词：multi biofeedback NEUROFEEDBACK ELECTROENCEPHALOGRAM phase lag index Parkinson’s disease
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