Gut microbiome,cognitive function and brain structure:a multi-omics integration analysis

查看全文 作　　者：Xinxiu [1,2]Liang;Yuanqing [2]Fu;Wen-ting [3,5]Cao;Zhihong [4,8]Wang;Ke [2]Zhang;Zengliang [2,6]Jiang;Xiaofang [4,8]Jia;Chun-ying [3]Liu;Hong-rou [3]Lin;Haili [3]Zhong;Zelei [2]Miao;Wanglong [2]Gou;Menglei [2]Shuai;Yujing [2]Huang;Shengdi [7]Chen;Bing [4,8]Zhang;Yu-ming [3]Chen;Ju-Sheng [2,6,9]Zheng

机构地区：[1]College of Life Sciences,Zhejiang University,Hangzhou 310058,China;[2]School of Life Sciences,Westlake University,18 Shilongshan Rd,Cloud Town,Hangzhou 310024,China;[3]Guangdong Provincial Key Laboratory of Food,Nutrition and Health,Department of Medical Statistics and Epidemiology,School of Public Health,Sun Yat-Sen University,Guangzhou 510080,China;[4]Chinese Center for Disease Control and Prevention,National Institute for Nutrition and Health,Beijing 100050,China;[5]School of Public Health,Hainan Medical University,Haikou 571199,China;[6]Westlake Intelligent Biomarker Discovery Lab,Westlake Laboratory of Life Sciences and Biomedicine,Hangzhou 310024,China;[7]Department of Neurology and Institute of Neurology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;[8]Key Laboratory of Trace Element Nutrition,National Health Commission,Beijing 100050,China;[9]Institute of Basic Medical Sciences,Westlake Institute for Advanced Study,Hangzhou 310024,China.

出　　处：《Translational Neurodegeneration》索引2022年第11卷第1期,共14页

基　　金：the National Natural Science Foundation of China(82073529,81903316,81773416,and 82103826);Zhejiang Ten-thousand Talents Program(2019R52039);Zhejiang Provincial Natural Science Foundation of China(LQ21H260002);CHNS received funding from the National Institutes of Health(NIH)(R01HD30880,R01AG065357,P30DK056350,and R01HD38700)from 1989 to 2019;was supported by the National Institutes of Health and National Institute of Diabetes and Digestive and Kidney Diseases(R01DK104371);the Carolina Population Center P2CHD050924,P30AG066615.The funders had no role in collecting data,study design,interpretation of data or the decision to submit the manuscript for publication. 摘　　要：Background:Microbiome-gut-brain axis may be involved in the progression of age-related cognitive impairment and relevant brain structure changes,but evidence from large human cohorts is lacking.This study was aimed to investigate the associations of gut microbiome with cognitive impairment and brain structure based on multi-omics from three independent populations.Methods:We included 1430 participants from the Guangzhou Nutrition and Health Study(GNHS)with both gut microbiome and cognitive assessment data available as a discovery cohort,of whom 272 individuals provided fecal samples twice before cognitive assessment.We selected 208 individuals with baseline microbiome data for brain magnetic resonance imaging during the follow-up visit.Fecal 16S rRNA and shotgun metagenomic sequencing,tar-geted serum metabolomics,and cytokine measurements were performed in the GNHS.The validation analyses were conducted in an Alzheimer’s disease case-control study(replication study 1,n=90)and another community-based cohort(replication study 2,n=1300)with cross-sectional dataset.Results:We found protective associations of specific gut microbial genera(Odoribacter,Butyricimonas,and Bac-teroides)with cognitive impairment in both the discovery cohort and the replication study 1.Result of Bacteroides was further validated in the replication study 2.Odoribacter was positively associated with hippocampal volume(β,0.16;95%CI 0.06-0.26,P=0.002),which might be mediated by acetic acids.Increased intra-individual alterations in gut microbial composition were found in participants with cognitive impairment.We also identified several serum metabolites and inflammation-associated metagenomic species and pathways linked to impaired cognition.Conclusions:Our findings reveal that specific gut microbial features are closely associated with cognitive impair-ment and decreased hippocampal volume,which may play an important role in dementia development. 关键词：Gut microbiome Cognitive impairment Brain structure METAGENOMICS Microbiome-gut-brain axis COHORT

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Gut microbiome,cognitive function and brain structure:a multi-omics integration analysis

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