Advances in the development of new biomarkers for Alzheimer’s disease

查看全文 作　　者：Timofey [1,2]O.Klyucherev;Pawel [1]Olszewski;Alena [1,2]A.Shalimova;Vladimir [3]N.Chubarev;Vadim [2,3]V.Tarasov;Misty [1]M.Attwood;Stina [4]Syvänen;Helgi [1]B.Schiöth

机构地区：[1]Department of Neuroscience,Functional Pharmacology,University of Upp-sala,Uppsala,Sweden;[2]Department of Pharmacology,Institute of Pharmacy,I.M.Sechenov First Moscow State Medical University,Moscow,Russia;[3]Institute of Translational Medicine and Biotechnology,I.M.Sechenov First Moscow State Medical University,Moscow,Russia;[4]Department of Public Health and Caring Sciences,Rudbeck Laboratory,Uppsala University,Uppsala,Sweden.

出　　处：《Translational Neurodegeneration》索引2022年第11卷第1期,共24页

基　　金：Uppsala University.HBS is supported by the Swedish Research Council and the Swedish Brain Foundation。 摘　　要：Alzheimer’s disease(AD)is a complex,heterogeneous,progressive disease and is the most common type of neurodegenerative dementia.The prevalence of AD is expected to increase as the population ages,placing an additional burden on national healthcare systems.There is a large need for new diagnostic tests that can detect AD at an early stage with high specificity at relatively low cost.The development of modern analytical diagnostic tools has made it possible to determine several biomarkers of AD with high specificity,including pathogenic proteins,markers of synaptic dysfunction,and markers of inflammation in the blood.There is a considerable potential in using microRNA(miRNA)as markers of AD,and diagnostic studies based on miRNA panels suggest that AD could potentially be determined with high accuracy for individual patients.Studies of the retina with improved methods of visualization of the fundus are also showing promising results for the potential diagnosis of the disease.This review focuses on the recent developments of blood,plasma,and ocular biomarkers for the diagnosis of AD. 关键词：Alzheimer’s disease Amyloid beta peptides Biomarkers BLOOD CYTOKINES INFLAMMATION MicroRNA Ocular biomarkers

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Advances in the development of new biomarkers for Alzheimer’s disease

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