A Biological Perspective of TLR8 Signaling in Host Defense and Inflammation

查看全文 作　　者：Funing [1]Bian;Dong [2]Yan;Xiaopeng [3]Wu;Chao [3]Yang

机构地区：[1]Clinical Laboratory,Chengxian People's Hospital,Longnan,China;[2]Department of Dermatology,Xijing Hospital,The Fourth Military Medical University,Xi’an,China;[3]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Centre for Infectious Diseases,Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China.

出　　处：《Infectious Microbes & Diseases》索引2023年第5卷第2期,共12页

摘　　要：Toll-like receptors(TLRs)play important roles in immune responses against pathogens and tumors.Recently,TLR8 has gained attention because of its association with multiple inflammatory diseases,infections and antitumor responses.TLR8 senses the degradation products of single-stranded RNA from microbes and self-released RNA to induce type I interferons,inflammatory gene expression and nucleotide-binding and oligomerization domain–,leucine-rich repeat–and pyrin domain–containing protein 3(NLRP3)inflammasome activation.So far,the understanding of TLR8 function in vivo is still limited,partially because of lacking a reliable rodent animal model.Murine Tlr8 cannot sense the ligands of human TLR8.In mammals,TLR8 distinguishes live bacteria from dead bacteria to regulate the magnitude of immune responses.Recently,TLR8 has been reported to recognize severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA to induce inflammatory responses,suggesting that TLR8 participates in coronavirus disease 2019(COVID-19).In this review,we discuss the mechanism of ligand recognition by TLR8,TLR8-mediated signaling pathways and signaling crosstalk between TLR8 and other molecules,and untangle the contribution of TLR8 to inflammatory diseases,infectious diseases,antitumor immunity and vaccination. 关键词：TLR8 signaling pathway DISEASES

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A Biological Perspective of TLR8 Signaling in Host Defense and Inflammation

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