Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

查看全文 作　　者：Erxi [1,2,3,4,5]Wu;Dan [1]Qi;Damir [1,2]Nizamutdinov;Jason [1,2,5]H.Huang

机构地区：[1]Department of Neurosurgery and Neuroscience Institute,Baylor Scott&White Health,Temple,TX,USA;[2]Texas A&M University School of Medicine,Temple,TX,USA;[3]Texas A&M University School of Pharmacy,College Station,TX,USA;[4]LIVESTRONG Cancer Institutes and Department of Oncology,Dell Medical School,the University of Texas at Austin,Austin,TX,USA;[5]Department of Neurosurgery,Baylor College of Medicine,Temple,TX,USA

出　　处：《Neural Regeneration Research》索引2024年第19卷第5期,共4页

基　　金：supported by the Corbett Estate Fund(62285-531021-41800,to EW);the Helen Vosburg McCrillus Plummer and Robert Edward Lee Plummer,Jr.Chair Fund(to JHH). 摘　　要：Neuron-astrocyte interactions are vital for the brain’s connectome.Understanding astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in mammals.Studies on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between neurons.Astrocytes,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic function.Recent research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel signaling.This summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical states.These findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and responsiveness.Targeting astrocytic signaling pathways shows promise for treating sleep disorders and arousal dysregulation.More research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders. 关键词：AROUSAL ASTROCYTE calcium waves locus coeruleus neuron-astrocyte interaction NOREPINEPHRINE SLEEP WAKEFULNESS

相关文献

参考文献（22）
引证文献（1）
耦合文献（0）

参考文献(22)

引证文献(1)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

参考文献(22)

引证文献(1)

用户提示