Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering

查看全文 作　　者：Yi [1]Yang;Kepin [1]Wang;Han [1]Wu;Qin [1]Jin;Degong [1]Ruan;Zhen [1]Ouyang;Bentian [1]Zhao;Zhaoming [1]Liu;Yu [1]Zhao;Quanjun [1]Zhang;Nana [1]Fan;Qishuai [1]Liu;Shimei [1,2]Guo;Lei [3]Bu;Yong [4]Fan;Xiaofang [4]Sun;Xiaoping [1]Li;Liangxue [1,5]Lai

机构地区：[1]Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine,South China Institute for Stem Cell Biology and Regenerative Medicine,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510530,China;[2]School of Life Sciences,University of Science and Technology of China,Hefei 230027,China;[3]Leon H Charney Division of Cardiology,New York University School of Medicine,522 First Avenue,New York,NY 10016,USA;[4]Key Laboratory for Major Obstetric Diseases of Guangdong Province,Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China;[5]Jilin Provincial Key Laboratory of Animal Embryo Engineering,Institute of Zoonosis,College of Veterinary Medicine,Jilin University,Changchun 130062,China

出　　处：《Journal of Molecular Cell Biology》索引2016年第8卷第2期,共4页

基　　金：supported by grants from the National Basic Research Program of China (973 programs) (2011CB944203,2011CB944204);the National High-Tech R&D Program of China (863 Programs) (2014AA021602);the National Natural Science Foundation of China (31401271);the Key Deployment Project of the Chinese Academy of Sciences (KSZD-EW-Z-005-003-002);the Science and Technology Planning Project of Guangdong Province,China (2014B030301058,2015A030310119);Bureau of Science and Technology of GuangzhouMunicipality (201505011111498). 摘　　要：Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. 关键词：ISLET injection EXPRESSING

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Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering

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