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CircUCP2 promotes the tumor progression of non-small cell lungcancer through the miR-149/UCP2 pathway

查看全文 作　　者：WEI [1]DU;FANG [1]YIN;YATING [1]ZHONG;MINJIE [1]LUO;ZHEN [2]WANG;PENG [2]LIN;QING [2]LIU;HAN [2]YANG 高影响力作者 机构地区：[1]Department of Pathology,The First People’s Hospital of Changde City,Changde,415000,China;[2]State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou,510000,China高影响力机构 出　　处：《Oncology Research》索引2023年第31卷第6期,共8页高影响力期刊 基　　金：supported by grants from the Science and Technology Program of Guangzhou(202102080084,Han Yang);the Key Project of Scientific Research Plan of Hunan Provincial Health Commission(C202301047982,Wei Du);the Wings Scientific and Technological Foundation of The First People’s Hospital of Changde City(2022ZZ05,Wei Du);the Traditional Chinese Medicine Bureau of Guangdong Province(20161062,Qing Liu). 摘　　要：Non-small cell lung cancer(NSCLC)is a highly lethal cancer,and better treatments are urgently needed.Many studies have implicated circular RNAs(circRNAs)in the progression of multiple malignant tumors.Nonetheless,the functions of circRNAs in NSCLC remain unclear.To study new targets for the treatment of NSCLC,circRNA expression profiling was performed on NSCLC tissues and para-carcinoma nonmalignant tissues.RNA was isolated and used for circRNA sequencing.Biological studies were performed in vitro and in vivo to determine the functions of circRNAs in NSCLC,including their functions in cell proliferation and migration.How circRNAs function in NSCLC was explored to clarify the underlying regulatory mechanisms.We found that circUCP2 was upregulated in NSCLC tissues compared with neighboring nonmalignant tissues.circUCP2 promoted the proliferation and metastasis of NSCLC cells.circUCP2 promoted NSCLC progression by sponging miR-149 and upregulating UCP2.The circUCP2/miR-149/UCP2 axis accelerates the progression of NSCLC,and circUCP2 may therefore be a novel diagnostic biomarker for the progression of NSCLC. 关 键 词：CircUCP2 miR-149 UCP2 CeRNAs NSCLC
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