Spectral and biodistributional engineering of deep near-infrared chromophore

查看全文 作　　者：Yan [1]Dong;Xicun [1]Lu;Yi [1]Li;Weichao [1]Chen;Lei [1]Yin;Jie [1]Zhao;Xinru [1]Hu;Xinran [1]Li;Zuhai [1]Lei;Yuyang [3]Wu;Hao [3]Chen;Xiao [1,2]Luo;Xuhong [1,2]Qian;Youjun [1]Yang

机构地区：[1]State Key Laboratory of Bioreactor Engineering,Shanghai Key Laboratory of Chemical Biology,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;[2]Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development,School of Chemistry and Molecular Engineering,East China Normal University,Shanghai 200241,China;[3]Molecular Imaging Center,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China

出　　处：《Chinese Chemical Letters》索引2023年第34卷第9期,共7页

基　　金：supported by the National Natural Science Foundation of China(Nos.21908065,22078098,and 22278138);the Shanghai Academic Technology Research Leader(No.22XD1421000);the Research Funds of Happiness Flower ECNU(No.2020JK2103);the Open Funding Project of the State Key Laboratory of Bioreactor Engineering。 摘　　要：Fluorescence-guided surgery calls for development of near-infrared fluorophores.Despite the wide-spread application and a safe clinical record of Indocyanine Green(ICG),its maximal absorption wavelength at780 nm is rather short and longer-wavelength dyes are desired to exploit such benefits as low phototoxicity and deep penetration depth.Here,we report ECY,a stable deep near-infrared(NIR)fluorochromic scaffold absorbing/emitting at 836/871 nm with a fluorescence quantum yield of 16%in CH_(2)Cl_(2).ECY was further rationally engineered for biological distribution specificity.Analogous bearing different numbers of sulfonate group or a polyethylene glycol chain were synthesized.By screening this focused library upon intravenous injection to BALB/c mice,ECYS2 was identified to be a suitable candidate for bioimaging of organs involved in hepatobiliary excretion,and ECYPEG was found to be a superior candidate for vasculature imaging.They have potentials in intraoperative imaging. 关键词：Near infrared fluorophore In vivo imaging Molecular engineering Biological distribution ANGIOGRAPHY

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Spectral and biodistributional engineering of deep near-infrared chromophore

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