Research advances in peptide-drug conjugates

查看全文 作　　者：Liming [1,2]Gong;Heming [1,2]Zhao;Yanhong [1,2]Liu;Hao [3]Wu;Chao [1,2]Liu;Shuangyan [1,2]Chang;Liqing [1,2]Chen;Mingji [1,2]Jin;Qiming [1,2]Wang;Zhonggao [1,2]Gao;Wei [1,2]Huang

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;[2]Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations,Department of Pharmaceutics,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;[3]Department of Pharmacy,Yanbian University,Yanji 133000,China

出　　处：《Acta Pharmaceutica Sinica B》索引2023年第13卷第9期,共19页

基　　金：supported by grants from CAMS Innovation Fund for Medical Sciences(CIFMS,China)(2021-I2M-1-026)。 摘　　要：Peptide-drug conjugates(PDCs)are drug delivery systems consisting of a drug covalently coupled to a multifunctional peptide via a cleavable linker.As an emerging prodrug strategy,PDCs not only preserve the function and bioactivity of the peptides but also release the drugs responsively with the cleavable property of the linkers.Given the ability to significantly improve the circulation stability and targeting of drugs in vivo and reduce the toxic side effects of drugs,PDCs have already been extensively applied in drug delivery.Herein,we review the types and mechanisms of peptides,linkers and drugs used to construct PDCs,and summarize the clinical applications and challenges of PDC drugs. 关键词：Peptide-drug conjugates PEPTIDES LINKERS Drug delivery systems Prodrug strategy

相关文献

参考文献（146）
引证文献（7）
耦合文献（0）

参考文献(146)

引证文献(7)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Research advances in peptide-drug conjugates

参考文献(146)

引证文献(7)

用户提示