Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease

查看全文 作　　者：LI [1]Yanwei;LU [2]Yunrui;NIAN [1]Mozuo;SHENG [1]Qiuju;ZHANG [1]Chong;HAN [1]Chao;DOU [1]Xiaoguang;DING [1]Yang

机构地区：[1]Department of Infectious Diseases,Shengjing Hospital of China Medical University,Shenyang 110000,China;[2]Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China

出　　处：《Chinese Journal of Natural Medicines》索引2023年第21卷第9期,共15页

基　　金：Liaoning Provincial Local Professional Technology Innovation Platform Construction Project(2016007013);Liaoning Provincial Natural Science Foundation(2014021007);Outstanding Scientiffc Fund of Shengjing Hospital(2011-02);345 Talent Project of Shengjing Hospital(2020-01);The Mechanism of Immune Tolerance Mediated by Myeloid-Derived Suppressor Cells inhibiting T Cell Immune Responses via PD-L1 in Chronic Hepatits B(2022-12). 摘　　要：Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue with scar tissue,and also the leading cause of liver-related death worldwide.During the treatment of liver fibrosis,in addition to antiviral therapy or removal of inducers,there remains a lack of specific and effective treatment strategies.For thousands of years,Chinese herbal medicines(CHMs)have been widely used to treat liver fibrosis in clinical setting.CHMs are effective for liver fibrosis,though its mechanisms of action are unclear.In recent years,many studies have attempted to determine the possible mechanisms of action of CHMs in treating liver fibrosis.There have been substantial improvements in the experimental investigation of CHMs which have greatly promoted the understanding of anti-liver fibrosis mechanisms.In this review,the role of CHMs in the treatment of liver fibrosis is described,based on studies over the past decade,which has addressed the various mechanisms and signaling pathways that mediate therapeutic efficacy.Among them,inhibition of stellate cell activation is identified as the most common mechanism.This article provides insights into the research direction of CHMs,in order to expand its clinical application range and improve its effectiveness. 关键词：Chinese herbal medicine Liver fibrosis Anti-hepatic fibrotic therapy Molecular mechanism Active ingredient

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Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease

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