维普中文期刊产品整合服务

Small molecules targeting protein-protein interactions for cancer therapy

查看全文 作　　者：Defa [1]Wu;Yang [1]Li;Lang [1]Zheng;Huan [1]Xiao;Liang [1]Ouyang;Guan [1]Wang;Qiu [1,2]Sun 高影响力作者 机构地区：[1]Department of Biotherapy,Cancer Center and State Key Laboratory of Biotherapy,Innovation Center of Nursing Research,West China Hospital,Sichuan University/West China School of Nursing,Sichuan University,Chengdu 610041,China;[2]West China Medical Publishers,West China Hospital,Sichuan University,Chengdu 610041,China高影响力机构 出　　处：《Acta Pharmaceutica Sinica B》索引2023年第13卷第10期,共29页高影响力期刊 基　　金：supported by Natural Science Foundation of Sichuan Province(Grants 2023NSFSC1839,2022NSFSC1290,China);the National Natural Science Foundation of China(Grant 22177083);the Sichuan University Postdoctoral Interdisciplinary Innovation Fund(JCXK2221,China);the Sichuan Science and Technology Program(2023NSFSC1688,China);the Full-time Postdoctoral Research and Development Fund of West China Hospital,Sichuan University(2023HXBH057,China)。 摘　　要：Protein-protein interactions(PPIs)are fundamental to many biological processes that play an important role in the occurrence and development of a variety of diseases.Targeting the interaction between tumour-related proteins with emerging small molecule drugs has become an attractive approach for treatment of human diseases,especially tumours.Encouragingly,selective PPI-based therapeutic agents have been rapidly advancing over the past decade,providing promising perspectives for novel therapies for patients with cancer.In this review we comprehensively clarify the discovery and development of small molecule modulators of PPIs from multiple aspects,focusing on PPIs in disease,drug design and discovery strategies,structure-activity relationships,inherent dilemmas,and future directions. 关 键 词：Protein‒protein interactions CANCER Small molecules Structure-activity relationships
相关文献

参考文献(227)

引证文献(6)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费