De novo nucleotide biosynthetic pathway and cancer

查看全文 作　　者：Jie [1,2]Chen;Siqi [1]Yang;Yingge [1,2]Li;Xu [2]Ziwen;Pingfeng [1]Zhang;Qibin [1]Song;Yi [1]Yao;Huadong [2]Pei 机构地区：[1]Cancer Center,Renmin Hospital of Wuhan University,Wuhan,Hubei 430062,China;[2]Lombardi Comprehensive Cancer Center,Georgetown University Medical Center,Washington,D.C.20057,USA 出　　处：《Genes & Diseases》索引2023年第10卷第6期,共8页 摘　　要：De novo nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms.Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation.Thus,the dysregulation of the de novo nucleotide biosynthetic pathway contributes to the development of many human diseases,such as cancer.It has been shown that many enzymes in this pathway are overactivated in different cancers.In this review,we summarize and update the current knowledge on the de novo nucleotide biosynthetic pathway,regulatory mechanisms,its role in tumorigenesis,and potential targeting opportunities. 关 键 词：Biosynthetic pathway CANCER de novo synthesis METABOLISM NUCLEOTIDE