Extracellular matrix and nitric oxide based functional coatings for vascular stents

查看全文 作　　者：Quhan [1]Cheng;Muhammad [2]Shafiq;Muhammad [1]Rafique;Li [3,4]Shen;Xiumei [2]Mo;Kai [1]Wang

机构地区：[1]Key Laboratory of Bioactive Materials,Ministry of Education,College of Life Sciences,Nankai University,Tianjin 300071,China;[2]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine,College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China;[3]Department of Cardiology,Shanghai Institute of Cardiovascular Diseases,Zhongshan Hospital,Fudan University,Shanghai 200032,China;[4]National Clinical Research Center for Interventional Medicine,Shanghai 200032,China.

出　　处：《Engineered Regeneration》索引2022年第3卷第2期,共5页

基　　金：supported by grants from the National Natural Science Foundation of China(82172106,32050410286)and Tian-jin'Project+Team'Key Training Foundation(XC202035);Science and Technology Commission of Shanghai Municipality(19441902600,20S31900900,20DZ2254900)。 摘　　要：Cardiovascular diseases cause huge morbidity and mortality worldwide.Recently,vascular stents have been most frequently used to treat cardiovascular diseases thanks to their effectiveness at dilating blood vessels and main-taining the circulation of blood.However,stent expansion leads to endothelium injury posing thrombogenic and in-stent restenosis(ISR).In addition,the bioinertness and an acute lack of endothelium-like function on the surface of implanted vascular stents compromise their performance.Functional coatings of vascular stents to mimic endothelium-and extracellular matrix(ECM)-like functions could prevent thrombosis,inhibit the over-growth of smooth muscle cells(SMCs),and promote the rapid restoration of native endothelium,hence effec-tively suppressing stent-related complications.Noticeably,ECM-based coatings including a multitude of bioactive molecular,such as growth factors,heparin,hyaluronic acid(HA)and so on,have been proven to play important effects on regulating ECs/SMCs behavior and improving blood compatibility of stents.Additionally,nitric oxide(NO),which is fundamental to the endothelium-mediated anti-thrombogenesity,anti-intimal hyperplasia and anti-inflammation,has been leveraged to improve vascular stent functions.Therefore,this review will highlight different strategies and biological role of ECM and NO based functional coatings on vascular stent.Lastly,some potential important factors for stents development are suggested as well. 关键词：Vascular stent Nitric oxide Extracellular matrix Functional coating

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Extracellular matrix and nitric oxide based functional coatings for vascular stents

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