Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

查看全文 作　　者：Ye [1,2,3]Peng;Lin [1,4]Zhang;Chris [2,3]K.P.Mok;Jessica [1,4]Y.L.Ching;Shilin [1,3,4]Zhao;Matthew [1,3]K.L.Wong;Jie [1,3]Zhu;Chunke [2,3]Chen;Shilan [1,4]Wang;Shuai [1]Yan;Biyan [1]Qin;Yingzhi [1,4]Liu;Xi [2,3]Zhang;Chun Pun [1,3,4]Cheung;Pui Kuan [1,4]Cheong;Ka Long [1,4]Ip;Adrian [5]C.H.Fung;Kenneth [5]K.Y.Wong;David [4,6]S.C.Hui;Francis [1,7]K.L.Chan;Siew [1,3,4]C.Ng;Hein [1,2,3]M.Tun 机构地区：[1]Microbiota I-Center(MaglC),Hong Kong,China;[2]Jockey Club School of Public Health and Primary Care,The Chinese University of Hong Kong,Hong Kong,China;[3]Li Ka Shing Institute of Health Sciences,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong,China;[4]Department of Medicine and Therapeutics,The Chinese University of Hong Kong,Hong Kong,China;[5]Department of Surgery,LKS Faculty of Medicine,The University of Hong Kong,Hong Kong,China;[6]Stanley Ho Centre for Emerging Infectious Diseases,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong,China;[7]Centre for Gut Microbiota Research,The Chinese University of Hong Kong,Hong Kong,China 出　　处：《Signal Transduction and Targeted Therapy》索引2023年第8卷第10期,共11页 基　　金：The study was supported by the Health and Medical Research Fund(HMRF)Commissioned Research Grant(COVID193002)(F.K.L.C.);Enhanced start-up research grant of CUHK(H.M.T.);Hui Hoy&Chow Sin Lan Charity Fund Limited(S.C.N.);the National Research Foundation of Korea(NRF)grant funded through the Korea government(NRF-2018M3A9H4055203)(C.K.P.M.);Emergency Key Program of Guangzhou Laboratory(Grant No.EKPG22-30-6)(C.K.P.M.). 摘　　要：The role of gut microbiota in modulating the durability of cOVID-19 vaccine immunity is yet to be characterised.In this cohort study,we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline,1 month,and 6 months post vaccination(p.v).Neutralisation antibody,plasma cytokine and chemokines were measured and associated with the gut microbiota and metabolome composition. 关 键 词：VACCINE IMMUNITY vaccines