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Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus(MRSA)-infected wounds in rabbits

查看全文 作　　者：Muhammad [1]Asif;Ayesha Safdar [1]Chaudhry;Ambreen [2]Ashar;Hamad Bin [1]Rashid;Muhammad Hassan [3]Saleem;Hassaan Bin [4]Aslam;Abdul [5]Aziz 高影响力作者 机构地区：[1]Department of Veterinary Surgery,University of Veterinary and Animal Sciences,Lahore,Punjab,Pakistan;[2]TECS Department,Wilson College of Textiles,NC State University,Raleigh 27606,USA;[3]Department of Veterinary Medicine,University of Veterinary and Animal Sciences,Lahore,Punjab,Pakistan;[4]Institute of Microbiology,University of Veterinary and Animal Sciences,Lahore,Punjab,Pakistan;[5]Department of Veterinary Clinical Sciences,University of Poonch,Rawalakot 12350,Pakistan高影响力机构 出　　处：《Asian Pacific Journal of Tropical Biomedicine》索引2023年第13卷第11期,共10页高影响力期刊 摘　　要：Objective:To synthesize zinc oxide nanoparticles(ZnONPs)and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus(MRSA).Methods:ZnONPs were prepared by sol-gel method and characterized by X-ray diffraction(XRD)analysis and scanning electron microscopy(SEM).A total of 18 rabbits were divided into three groups:the ZnONPs group,the gentamicin group and the control group.A wound of 3 cm^(2) was inflicted on each rabbit and contaminated with MRSA inoculum.Treatment was started from the fourth day post-surgery.Wound healing,microbiological analysis,and histopathological analysis were performed to assess the efficacy of ZnONPs ointment.Results:XRD analysis confirmed the hexagonal wurtzite structure of the ZnONPs with an average crystallite size of 29.23 nm.SEM revealed discoid-shaped ZnONPs with a rough surface and an average size of 48.36 nm.Energy-dispersive X-ray analysis confirmed the purity of ZnONPs.Moreover,the particle size ranged from 100-700 nm with a high agglomeration trend.Treatment with ZnONPs promoted MRSA-infected wound healing.In addition,ZnONPs showed a good antibacterial effect as evidenced by a dose-dependent increase in the zone of inhibition.Conclusions:ZnONPs accelerate the healing of MRSA-infected wounds.Therefore,it can be explored for the treatment of MRSA infection. 关 键 词：MRSA Wound healing ZnO NANOPARTICLES OINTMENT
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