Glutamine addiction and therapeutic strategies in pancreatic cancer

查看全文 作　　者：Lin-Lin [1]Ren;Tao [1]Mao;Pin [1]Meng;Li [2]Zhang;Hong-Yun [1]Wei;Zi-Bin [1]Tian

机构地区：[1]Department of Gastroenterology,The Affiliated Hospital of Qingdao University,Qingdao 266000,Shandong Province,China;[2]Department of Pathology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China

出　　处：《World Journal of Gastrointestinal Oncology》索引2023年第15卷第11期,共12页

基　　金：Supported by the National Natural Science Foundation of China,No.81602056 and No.82273393;the Natural Science Foundation of Shandong Province,No.ZR2016HQ45 and No.ZR2020LZL004;the Shandong Traditional Chinese Medicine Science and Technology Project,No.2021M161. 摘　　要：Pancreatic cancer remains one of the most lethal diseases worldwide owing to its late diagnosis,early metastasis,and poor prognosis.Because current therapeutic options are limited,there is an urgent need to investigate novel targeted treatment strategies.Pancreatic cancer faces significant metabolic challenges,principally hypoxia and nutrient deprivation,due to specific microenvironmental constraints,including an extensive desmoplastic stromal reaction.Pancreatic cancer cells have been shown to rewire their metabolism and energy production networks to support rapid survival and proliferation.Increased glucose uptake and glycolytic pathway activity during this process have been extensively described.However,growing evidence suggests that pancreatic cancer cells are glutamine addicted.As a nitrogen source,glutamine directly(or indirectly via glutamate conversion)contributes to many anabolic processes in pancreatic cancer,including amino acids,nucleobases,and hexosamine biosynthesis.It also plays an important role in redox homeostasis,and when converted toα-ketoglutarate,glutamine serves as an energy and anaplerotic carbon source,replenishing the tricarboxylic acid cycle intermediates.The present study aims to provide a comprehensive overview of glutamine metabolic reprogramming in pancreatic cancer,focusing on potential therapeutic approaches targeting glutamine metabolism in pancreatic cancer. 关键词：Pancreatic cancer Glutamine metabolism Cancer treatment Therapeutic strategies

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Glutamine addiction and therapeutic strategies in pancreatic cancer

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