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Phenome-wide association study and precision medicine of cardiovascular diseases in the post-COVID-19 era

查看全文 作　　者：Qian [1]Cao;Xin [1]Du;Xiao-yan [1]Jiang;Yuan [1]Tian;Chen-hao [1]Gao;Zi-yu [1]Liu;Ting [1]Xu;Xing-xing [1]Tao;Ming [1]Lei;Xiao-qiang [1]Wang;Lingyu Linda [1,2,3]Ye;Dayue Darrel [1,2,3,4]Duan 高影响力作者 机构地区：[1]Center for Phenomics of Traditional Chinese Medicine,the Affiliated Traditional Chinese Medicine Hospital,Southwest Medical University,Luzhou,646000,China;[2]Institute of Integrated Chinese and Western Medicine,Southwest Medical University,Luzhou,646000,China;[3]Key Laboratory of Autoimmune Diseases and Precision Medicie,People’s Hospital of Ningxia Hui Autonomous Region,Yinchuan,750001,China;[4]The Department of Pharmacology,University of Nevada Reno School of Medicine,Reno,NV,89557,USA高影响力机构 出　　处：《Acta Pharmacologica Sinica》索引2023年第44卷第12期,共11页高影响力期刊 基　　金：the Science and Technology strategic cooperation Programs of Luzhou Municipal People’s Government and Southwest Medical University(NO.2017LZXNYD-P01 and 2019 LZXNYD-P01DUAN to Dr.Duan). 摘　　要：SARS-CoV-2 infection causes injuries of not only the lungs but also the heart and endothelial cells in vasculature of multiple organs,and induces systemic inflammation and immune over-reactions,which makes COVID-19 a disease phenome that simultaneously affects multiple systems.Cardiovascular diseases(CVD)are intrinsic risk and causative factors for severe COVID-19 comorbidities and death.The wide-spread infection and reinfection of SARS-CoV-2 variants and the long-COVID may become a new common threat to human health and propose unprecedented impact on the risk factors,pathophysiology,and pharmacology of many diseases including CVD for a long time.COVID-19 has highlighted the urgent demand for precision medicine which needs new knowledge network to innovate disease taxonomy for more precise diagnosis,therapy,and prevention of disease.A deeper understanding of CVD in the setting of COVID-19 phenome requires a paradigm shift from the current phenotypic study that focuses on the virus or individual symptoms to phenomics of COVID-19 that addresses the inter-connectedness of clinical phenotypes,i.e.,clinical phenome.Here,we summarize the CVD manifestations in the full clinical spectrum of COVID-19,and the phenome-wide association study of CVD interrelated to COVID-19.We discuss the underlying biology for CVD in the COVID-19 phenome and the concept of precision medicine with new phenomic taxonomy that addresses the overall pathophysiological responses of the body to the SARS-CoV-2 infection.We also briefly discuss the unique taxonomy of disease as Zheng-hou patterns in traditional Chinese medicine,and their potential implications in precision medicine of CVD in the post-COVID-19 era. 关 键 词：COVID-19 cardiovascular disease PheWAS precision medicine Traditional Chinese Medicine
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