Immunology demystified: A guide for transplant hepatologists

查看全文 作　　者：Iva [1]Kosuta;Tomislav [2,3]Kelava;Ana [4]Ostojic;Vibor [1]Sesa;Anna [5]Mrzljak;Hrvoje [6,7,8]Lalic 机构地区：[1]Department of Intensive Care Medicine,University Hospital Centre Zagreb,Zagreb 10000,Croatia;[2]Department of Physiology,School of Medicine,Univeristy of Zagreb,Zagreb 10000,Croatia;[3]Laboratory for Molecular Immunology,Croatian Institute for Brain Research,Zagreb 10000,Croatia;[4]Department of Gastroenterology and Hepatology,Liver Transplant Center,University Hospital Centre Zagreb,Zagreb 10000,Croatia;[5]Department of Medicine,School of Medicine,University of Zagreb,Zagreb 10000,Croatia;[6]Department of Physiology,University of Zagreb School of Medicine,Zagreb 10000,Croatia;[7]Laboratory for Cell Biology,Croatian Institute for Brain Research,University of Zagreb School of Medicine,Zagreb 10000,Croatia;[8]Department of Laboratory Immunology,Clinical Department of Laboratory Diagnostics,University Hospital Center Zagreb,Zagreb 10000,Croatia 出　　处：《World Journal of Transplantation》索引2024年第14卷第1期,共14页 摘　　要：Liver transplantation has become standard practice for treating end-stage liver disease.The success of the procedure relies on effective immunosuppressive medications to control the host's immune response.Despite the liver's inherent capacity to foster tolerance,the early post-transplant period is marked by significant immune reactivity.To ensure favorable outcomes,it is imperative to identify and manage various rejection types,encompassing T-cell-mediated,antibody-mediated,and chronic rejection.However,the approach to prescribing immunosuppressants relies heavily on clinical judgment rather than evidencebased criteria.Given that the majority of patients will require lifelong immunosuppression as the mechanisms underlying operational tolerance are still being investigated,healthcare providers must possess an understanding of immune responses,rejection mechanisms,and the pathways targeted by immunosuppressive drugs.This knowledge enables customization of treatments and improved patient care,even though a consensus on an optimal immunosuppressive regimen remains elusive. 关 键 词：Liver transplantation Allograft rejection Operational immune tolerance Immune reaction IMMUNOSUPPRESSION