TT virus infection in patients with chronic hepatitis B and response of TTV to lamivudine

查看全文 作　　者：Javier Moreno [1]Garcia;Rafael Barcena [1]Marugan;Gloria Moraleda [1]Garcia;M Luisa Mateos [2]Lindeman;Jesus Fortun [3]Abete;Santos del Campo [1]Terron

机构地区：[1]Department of Gastroenterology,Hospital Ramony Cajal,Madrid,Spain;[2]Department of Microbiology,Hospital Ramony Cajal,Madrid,Spain;[3]Department of Infectious Diseases,Hospital Ramony Cajal,Madrid,Spain

出　　处：《World Journal of Gastroenterology》索引2003年第9卷第6期,共4页

基　　金：Fundacion Manchega de Investigaciony Docencia en Gastroenterologia 摘　　要：AIM: To investigate the responses of TT virus (TTV) and hepatitis B virus (HBV) to a long-term lamivudine therapy.METHODS: Sixteen patients infected with both TTV and HBV were treated with lamivudine 100 mg daily for 30 months. Blood samples were drawn at the beginning of the therapy and subsequently at month 3, 6, 9, 12 and 30.Serum TTV was quantified by real time PCR and serum HBV was detected by hybridization assay and nested polymerase chain reaction.RESULTS: TTV infection was detected in 100 % of HBV-infected patients. Loss of serum TTV DNA after one year of treatment occurred in 1/16 (6 %) patients. At the end of therapy, TTV DNA was positive in 94 % of them. The decline of HBV viremia was evident at 3 months after therapy and the response rate was 31%, 44 %, 63 %, 50 % and 50 %at month 3, 6, 9, 12 and 30, respectively.CONCLUSION: TTV replication is not sensitive to lamivudine and is highly prevalent in HBV-infected patients. 关键词：TT病毒乙型肝炎病毒拉米夫定疗效

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TT virus infection in patients with chronic hepatitis B and response of TTV to lamivudine

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