Antitumor and immunomodulatory activity of resveratrol on experimentally implanted tumor of H22 in Balb/c mice

查看全文 作　　者：Hong-Shan Liu Cheng-En Pan Wei Yang Xue-Min Liu Department of Hepatobiliary Surgery,First Affiliated Hospital,Xi’an Jiaotong University,Xi’an 710061,Shaanxi Province,China

出　　处：《World Journal of Gastroenterology》索引2003年第9卷第7期,共3页

摘　　要：AIM: To study the antitumor and immunomodulatory activity of resveratrol on experimentally implanted tumor of H22 in Balb/c miceMETHODS: The cytotoxicity of peritoneal macrophages (M φ ) against H22 cells was measured by the radioactivity of [3H]TdR assay, mice with H22 tumor were injected with different concentrations of resveratrol, and the inhibitory rates were calculated and IgG contents were determined by single immunodiffusion method. the plaque forming cell (PFC) was measured by improved Cunningham method, the levels of serum tumor necrosis factor-α (TNF-α) were measured by cytotoxic assay against L929 cells.implanted tumor of H22 in mice. The inhibitory rates were 31.5 %, 45.6 % and 48.7 %, respectively (P<0.05), which could raise the level of serum IgG and PFC response to production of serum TNF-α in mice H22 tumor. However,the effect of resveratrol was insignificant (P >0.05).CONCLUSION: Resveratrol could inhibit the growth of H22tumor in Balb/c mice. The antitumor effect of resveratrol might be related to directly inhibiting the growth of H22cells and indirectly inhibiting its potential effect on nonspecific host immunomodulatory activity. 关键词：抗肿瘤药免疫调节剂白藜芦醇 H22肿瘤巨噬细胞动物实验

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Antitumor and immunomodulatory activity of resveratrol on experimentally implanted tumor of H22 in Balb/c mice

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