Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

查看全文 作　　者：Prachya [1]Kongtawelert;Pisit [2]Tangkijvanich;Siriwan Ong-[1]Chai;Yong [3]Poovorawan

机构地区：[1]Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200 Thailand;[2]Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330 Thailand;[3]Viral Hepatitis Research Unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330 Thailand

出　　处：《World Journal of Gastroenterology》索引2003年第9卷第10期,共4页

基　　金：the National Research Council,Bangkok;the Center of Excellent Found,Center of Excellence Viral Hepatitis Research Unit,Faculty of Medicine,Chulalongkom University;the Thailand Research Fund;Senior Research Scholar(YP);Junior Research Scholar(PK) 摘　　要：AIM:This study was designed to evaluate the clinical application of serum total sialic acid (TSA) in the diagnosis of cholangiocarcinoma (CCA).METHODS: Serum TSA was determined by periodateresorcinol microassay in 69 patients with CCA, 59 patients with hepatocellular carcinoma (HCC), 37 patients with cirrhosis, 61 patients with chronic hepatitis and 50 healthy blood donors.RESULTS: The mean serum TSA concentration in CCA (2.41±0.70 mmol/L) was significantly higher than those of HCC, cirrhosis, chronic hepatitis and healthy blood donors (1.41±0.37 mmol/L, 1.13±0.31 mmol/L, 1.16±0.26 mmol/L, and 1.10±0.14 mmol/L, respectively; P<0.001). Based on ROC curve analysis, a cut-off point of 1.75 mmol/L discriminated between CCA and HCC with a sensitivity,specificity and accuracy of 82.6%, 83.1%, and 82.8%,respectively.CONCLUSION: Based on our results, serum TSA would be a useful marker for the differential diagnosis of CCA from HCC. 关键词：胆管癌肝细胞癌鉴别诊断血清学检查硅铝酸

相关文献

参考文献（18）
引证文献（4）
耦合文献（70）

参考文献(18)

引证文献(4)

耦合文献(70)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

参考文献(18)

引证文献(4)

耦合文献(70)

用户提示