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N-acetylcysteine attenuates alcohol-induced oxidative stess in rats

查看全文 作　　者：Resat [1]Ozaras;Veysel [2]Tahan;Seval [3]Aydin;Hafize [3]Uzun;Safiye [3]Kaya;Hakan [2]Senturk 高影响力作者 机构地区：[1]Department of Infectious Diseases and Clinical Microbiology,University of Istanbul,Istanbul,Turkey;[2]Department of Internal Medicine,University of Istanbul,Istanbul,Turkey;[3]Department of Biochemistry,University of Istanbul,Istanbul,Turkey高影响力机构 出　　处：《World Journal of Gastroenterology》索引2003年第9卷第4期,共4页高影响力期刊 基　　金：the research Fund of the University of Istanbul,Project Number:T-589/240698 摘　　要：AIM: To investigate free-radical scavenger effect of nacetylcysteine in rats intragastrically fed with ethanol.METHODS: Twenty-four rats divided into three groups were fed with ethanol (6 g/kg/day, Group 1), ethanol and nacetylcysteine (1 g/kg, Group 2), or isocaloric dextrose (control group, Group 3) for 4 weeks. Then animals were sacrificed under ether anesthesia, and intracardiac blood and liver tissues were obtained. Measurements were made in both serum and homogenized liver tissues.Malondialdehyde (MDA) level was measured by TBARS method. Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) levels were studied by commercial kits.Kruskal-Wallis test was used for statistical analysis.RESULTS: ALT and AST in Group 1 (154 U/L and 302 U/L,respectively) were higher than those in Group 2 (94 U/L and 155 U/L) and Group 3 (99 U/L and 168 U/L) (P=0.001for both). Serum and tissue levels of MDA in Group 1 (1.84nmol/mL and 96 nmol/100 mg-protein) were higher than that in Group 2 (0.91 nmol/mL and 64 nmol/100 mg protein)and Group 3 (0.94 nmol/mL and 49 nmol/100 mg-protein)(P<0.001 for both). On the other hand, serum GSH-Px level in Group 1 (8.21 U/g Hb) was lower than that in Group 2(16 U/g Hb) and Group 3 (16 U/g-Hb) (P<0.001). Serum and liver tissue levels of SOD in Group 1 (11 U/mL and 26U/100 mg-protein) were lower than that in Group 2 (18 U/mL and 60 U/100 mg protein) and Group 3 (20 U/mL and 60 U/100 mg-protein) (P<0.001 for both).CONCLUSION: Ethanol-induced liver damage was associated with oxidative stress, and co-administration of n-acetylcysteine attenuates this damage effectively in rat model. 关 键 词：N-乙酰半胱氨酸 酒精 氧化损伤 动物实验 氧自由基 超氧化物歧化酶 谷胱苷肽过氧化酶 肝功能
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