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| 1 | Designing glucokinasc activators with reduced hypoglycemia risk: discovery of N,N-dimethyl- 5-(2-methyt-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy) pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus显示文摘 | Pfefferkorn J A Guzman-Perez A Oates P L | 2011 | Med Chem Comm2011，2，9： | 1 |
| 2 | Novel benzothiazole deriva- tives with a broad antifungal spectrum: design, synthesis and structure-activity relationships 显示文摘 | LIU Y WANG Y DONG G | 2013 | Med Chem Comm2013，4，12： | 1 |
| 3 | Alkynylation of N-(3-iodopyridin-2-yl)sulfonamide under Pd/C-Cu catalysis:a direct one pot synthesis of 7-azaindoles and their pharmacological evaluation as potential inhibitors of sirtuins显示文摘 | Layek M Syam Kumar Y Islam A | 2011 | Med Chem Comm2011，2，6： | 1 |
| 4 | Superiority of a novel EGFR targeted covalent inhibitor over its reversible counterpart in overcoming drug resistance 显示文摘 | Singh J Evans E Hagel M | 2012 | Med Chem Comm2012，3，7： | 1 |
| 5 | Synthesis and anti-tubercular activity of conformationally-constrained and bisquinoline analogs of TMC207显示文摘 | KALIA D KUMAR A K MEENA G | 2015 | Med Chem Comm2015，6，8： | 1 |
| 6 | HIV-1 protcasc in- hibitors with a tertiary alcohol containing transition-state mimic and various P2 and P1 substituents 显示文摘 | OHRNGREN P WU X PERSSON M | 2011 | Med Chem Comm2011，2，8： | 1 |
| 7 | Crafting precise multivalent architectures显示文摘 | Levine PM Carberry TP Holub JM | 2013 | Med Chem Comm2013，4，3： | 1 |
| 8 | Design of potential bisubstrate inhibitors against(Mtb)1-deoxy-D-xylulose 5-phosphate reductoisomerase(Dxr)-evidence of a novel binding mode显示文摘 | San J G Jackson E R Uh E | 2013 | Med Chem Comm2013，4，7： | 1 |
| 9 | Novel pyrazolopyridines as PI3K inhibitors:variation of the central linker group显示文摘 | Kendall J D Marshall A J Giddens A C | 2014 | Med Chem Comm2014，5，1： | 1 |
| 10 | Chemical space as a source for new drugs显示文摘 | Reymond J L Ruddigkeit L Blum L C | 2010 | Med Chem Comm2010，1，1： | 1 |
| 11 | A class of novel AA-Trp-Trp-OBzl:Synthesis,in vitro anti-proliferation,in vivo anti-tumor action,and intercalation mechanism显示文摘 | Liu L Wei L Yang Y | 2011 | Med Chem Comm2011，2，： | 1 |
| 12 | Transdermal delivery of in- sulin using solid-in-oil nanodispersion enhanced by arginine-rich peptides 显示文摘 | Yoshiiro Tahara Honda S | 2012 | Med Chem Comm2012，3，12： | 1 |
| 13 | 3-Substituted coumarins as dual inhibitors of ACh E and MAO for the treatment of Alzheimer′s disease显示文摘 | Vi觡a D Matos MJ Yá觡ez M | 2012 | Med Chem Comm2012，3，2： | 1 |
| 14 | Chemical motifs that redox cycle and their associated toxicity 显示文摘 | RANA P NAVEN R NARAYANAN A | 2013 | Med Chem Comm2013，4，8： | 1 |
| 15 | Design, synthesis, and biological activity of N-alkylated analogue Of NCLI, a selective inhibitor of lysine- specific demethylase 1显示文摘 | Khan M N A Tsumoto H Itoh Y | 2015 | Med Chem Comm2015，6，3： | 1 |
| 16 | Pyrrole- and indole-containing tranyleypromine derivatives as novel lysine-specific demetbylase 1 inhibitors active on cancer cells显示文摘 | Rodriguez V Valente S Rovida S | 2015 | Med Chem Comm2015，6，4： | 1 |
| 17 | More than just a GPCRligand: structure-based discovery of thioridazine derivativesas pim-1 kinase inhibitors显示文摘 | Li Wei Wan Xiaobo Zeng Fanqi | 2014 | Med Chem Comm2014，5，4： | 1 |
| 18 | Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1 显示文摘 | KHAN M N A TSUMOTO H ITOH v | 2015 | Med Chem Comm2015，6，： | 1 |
| 19 | Novel quinoline-derived mTOR inhibitors with remarkable enzymatic and cellular activities:design, synthesis and biological evaluation 显示文摘 | Ma X Qiu N Yang B | 2016 | Med Chem Comm2016，7，： | 1 |
| 20 | Understanding and overcoming aminoglyco- side resistance caused by N-6'-acetyltransferase显示文摘 | Vong K Auclair K | 2012 | Med Chem Comm2012，3，4： | 1 |
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