| 1 | Protective effect of Prostane in experimental prostatic hyperplasia in rats显示文摘Aim: Prostane, a polyherbal formulation, was evaluated for its efficacy on ,5a-reductase inhibition, a-adrenergie anta-gonistic activity and testosterone-induced prostatic hypeqllasia. Methods: 5a-reductase inhibition was evaluated usingrat prostate hornogeante as an enzyme source. Adrenergic antagonistic' activity was evaluated using isolated rat vas def-erens. Experimental prostatic hyperplasia was induced in rats by' giving testosterone 3 mg/kg sc for 21 days. Re-suits: Prostane dose-dependently inhibited 5a-reductase aetivity and exhibited a-adrenergic antagonistic activity. Treat-ment with Prostane at 250, 500 and 750 mg/kg body wt, po for 21 days significantly reduced the prostatic weight, theepithelial height and the stroinal proliferation in experimental prostatic hypertrophy. Conclusion: Prostane is effectivein the treatment of experimental prostatic hypertrophy in rats and may be passed on to clinical trials on benign prostatichypertrophy after necessary toxicological evaluations. ( Asian J Androl 1999 Dec ; l : 175 - t79 ) | S.K.Mitra R.Sundaram A.R.Mohan S.Gopumadhavan M.V.Venkataranganna Udupa Venkatesha S.J.Seshadri S.D.Autrulikar | 1999 | Asian Journal of Andrology1999，1，4： | 2 |
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