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| 1 | Human papilloma virus and esophageal carcinoma in a Latin-American region显示文摘AIM:To investigate the presence of high-risk human papilloma virus (HPV) in esophageal squamous cell carcinomas (ESCCs) in a non-selected Mexican population.METHODS: Cases with a pathological diagnosis of squamous cell carcinoma of the esophagus were obtained from Department of Pathology files, at the National Cancer Institute in Mexico City during the period between 2000 and 2008. Slides from each case were reviewed and cases with sufficient neoplastic tissue were selected for molecular analysis. DNA was extracted from paraffin-embedded tissue samples for polymerase chain reaction analysis to detect HPV DNA sequences. Demographic and clinical data of each patient were retrieved from corresponding clinical records.RESULTS: HPV was detected in 15 (25%) of ESCCs. HPV-16 was the most frequently observed genotype, followed by HPV-18; HPV-59 was also detected in one case. Unfortunately, HPV genotype could not be established in three cases due to lack of material for direct sequencing, although universal primers detected the presence of HPV generic sequences. No low-risk HPV genotypes were found nor was HPV-16/18 co-infection. HPV presence in ESCC was not significantly associated with gender, age, alcohol consumption, smoking, anatomic location, or histologic grade. All patients belonged to low and very low socioeconomic strata, and were diagnosed at advanced disease stage. Male patients were most commonly affected and the male:female ratio in HPV-positive ESCC increased two- fold in comparison with HPV-negative cases (6.5:1 vs 3.1:1).CONCLUSION: High prevalence of high-risk HPV in ESCC in Mexico does not support the hypothesis that HPV-associated ESCC is more common in areas with higher ESCC incidence rates. | Roberto Herrera-Goepfert Marcela Lizano Suminori Akiba Adela Carrillo-García Mauricio Becker-D'Acosta | 2009 | World Journal of Gastroenterology2009，15，25： | 4 |
| 2 | Betulinic acid hydroxamate prevents colonic inflammation and fibrosis in murine models of inflammatory bowel disease显示文摘Intestinal fibrosis is a common complication of inflammatory bowel disease (IBD) and is defined as an excessive accumulation of scar tissue in the intestinal wall. Intestinal fibrosis occurs in both forms of IBD: ulcerative colitis and Crohn’s disease. Small-molecule inhibitors targeting hypoxia-inducing factor (HIF) prolyl-hydroxylases are promising for the development of novel antifibrotic therapies in IBD. Herein, we evaluated the therapeutic efficacy of hydroxamate of betulinic acid (BHA), a hypoxia mimetic derivative of betulinic acid, against IBD in vitro and in vivo. We showed that BAH (5–20 μM) dose-dependently enhanced collagen gel contraction and activated the HIF pathway in NIH-3T3 fibroblasts;BAH treatment also prevented the loss of trans-epithelial electrical resistance induced by proinflammatory cytokines in Caco-2 cells. In two different murine models (TNBS- and DSS-induced IBD) that cause colon fibrosis, oral administration of BAH (20, 50 mg/kg·d, for 17 days) prevented colon inflammation and fibrosis, as detected using immunohistochemistry and qPCR assays. BAH-treated animals showed a significant reduction of fibrotic markers (Tnc, Col1a2, Col3a1, Timp-1, α-SMA) and inflammatory markers (F4/80+, CD3+, Il-1β, Ccl3) in colon tissue, as well as an improvement in epithelial barrier integrity and wound healing. BHA displayed promising oral bioavailability, no significant activity against a panel of 68 potential pharmacological targets and was devoid of genotoxicity and cardiotoxicity. Taken together, our results provide evidence that oral administration of BAH can alleviate colon inflammation and colitis-associated fibrosis, identifying the enhancement of colon barrier integrity as a possible mechanism of action, and providing a solid rationale for additional clinical studies. | María EPrados Adela García-Martín Juan DUnciti-Broceta Belén Palomares Juan ACollado Alberto Minassi Marco ACalzado Giovanni Appendino Eduardo Muñoz | 2021 | Acta Pharmacologica Sinica2021，42，7： | 3 |
| 3 | Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved显示文摘The pathological implication of amyloid precursor protein(APP)in Alzheimer’s disease has been widely documented due to its involvement in the generation of amyloid-β peptide.However,the physiological functions of APP are still poorly understood.APP is considered a multimodal protein due to its role in a wide variety of processes,both in the embryo and in the adult brain.Specifically,APP seems to play a key role in the proliferation,differentiation and maturation of neural stem cells.In addition,APP can be processed through two canonical processing pathways,generating different functionally active fragments:soluble APP-α,soluble APP-β,amyloid-β peptide and the APP intracellular C-terminal domain.These fragments also appear to modulate various functions in neural stem cells,including the processes of proliferation,neurogenesis,gliogenesis or cell death.However,the molecular mechanisms involved in these effects are still unclear.In this review,we summarize the physiological functions of APP and its main proteolytic derivatives in neural stem cells,as well as the possible signaling pathways that could be implicated in these effects.The knowledge of these functions and signaling pathways involved in the onset or during the development of Alzheimer’s disease is essential to advance the understanding of the pathogenesis of Alzheimer’s disease,and in the search for potential therapeutic targets. | Raquel Coronel Charlotte Palmer Adela Bernabeu-Zornoza María Monteagudo Andreea Rosca Alberto Zambrano Isabel Liste | 2019 | Neural Regeneration Research2019，14，10： | 2 |
| 4 | Reduetion of chilling injury symptoms in Persimmon fruit Rojo'Brillanie' by 1- MCP显示文摘 | ALEJANDR S LUEYA A ADELA M | 2004 | Postharvest Biol Teehnol2004，33，3： | 1 |
| 5 | Growth performance intestinal microbial populations of growing pigs fed diets containing sucrose thermal oligosaecharide caramel显示文摘 | ORBAN J I PATTERSON J A ADELA O | 1997 | Journal of Animal Science1997，75，： | 1 |
| 6 | Delayed ripening of 'Bartlett' pears treated with nitric oxide显示文摘 | GABRIEL O S GUSTAVO D T ADELA A F | 2003 | Journal of Horticultural Science and Biotechnology2003，78，6： | 1 |
| 7 | Determination of total selenium and selenium distribution in the milk phases in commercial cow's milk by HG-AAS显示文摘 | Cocar M N Raquel D G Adela B B Jos6 A C Jos6 M F Pilar B B | 2005 | Analytical and Bioanalytical Chemistry2005，381，6： | 1 |
| 8 | Programmed cell death during the transition from muhicellular structures to globular embryos in barley androgenesis显示文摘 | DE SIMONE F M GAUSSAND A P ADELA O | 2005 | Planta2005，221，： | 1 |
| 9 | Vohammetric and Spectrophotometric Techniques for the Determination of the Antihypertensive Drug Prazosin in Urine and Formulations 显示文摘 | Adela A Susana F B Camlo E | 1999 | J Pharm Biomed Anal1999，21，： | 1 |
| 10 | Voltammetric and speetrophotometric techniques for the determination of the antihypertensive drug Prazosin in urine and formulations显示文摘 | ADELA A SUSANA F B CAMILO E | 1999 | J Pharm Biomed Anal1999，21，： | 1 |
| 11 | Pharmacogenetics implementation in the clinics:information and guidelines for germline variants显示文摘The aim of this work was to supply an overview of the germline Pharmacogenetics that can be already implemented in the oncology clinical practice.An explanation of the three pillars considered necessary for determining which genetic polymorphisms should be used has been provided.These are PharmGKB single nucleotide polymorphism(SNP)-Drug Clinical Annotations with levels of evidence 1 or 2;the genetic information provided in the drug labels by the drug regulatory main agencies(Food and Drug Administration and European Medicines Agency,mainly);and the guidelines elaborated by international expert consortia(mainly Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group).A summary of the relevant SNPs and the recommendations on how to apply their results has also been compiled. | Gladys Olivera Luis Sendra María JoséHerrero Pablo Berlanga Pablo Gargallo Yania Yáñez Andrea Urtasun Jaime Font de Mora Victoria Castel Adela Cañete Salvador FAliño | 2019 | Cancer Drug Resistance2019，2，1： | 1 |
| 12 | Investigation of a solid fuel seramjet combustor 显示文摘 | Adela B Y Natan B Gany A | 1998 | Journal of Propulsion and Power1998，14，4： | 1 |
| 13 | α -L-Arabino furanosidase activity during development and ripening of normal and ACC synthase antisense tomato fruit显示文摘 | Gabriel O Sozzi Adela A Fraschina | 2002 | Hort Science2002，37，3： | 1 |
| 14 | Growth Performance Intestinal Microbial Populations of Growing Pigs Fed Diets Containing Sucrose Thermal Oligosaccharide Caramel 显示文摘 | Orban J I Patterson J A Adela O | 1997 | Journal of Animal Science1997，75，： | 1 |
| 15 | Proteomics and gene expression analyses of squalene-supplemented mice identify microsomal thioredoxin domain-containing protein 5 changes associated with hepatic steatosis显示文摘 | Adela Ramírez-Torres Sílvia Barceló-Batllori Roberto Martínez-Beamonte María A. Navarro Joaquín C. Surra Carmen Arnal Natalia Guillén Sergio Acín Jesús Osada | 2012 | Journal of Proteomics2012，，： | 1 |
| 16 | Coinicai rating sys- tems for the ankle- hindfoot, midfoot, hallux and lesser toes 显示文摘 | Kitaoka H A lexander 1 Adela R | 1994 | Foot ankie ctin1994，15，7： | 1 |
| 17 | Convenient QSAR model for predicting the complexation of structurally diverse compounds with β-cyclodextrins显示文摘 | Alfonso P G Aliuska M H Adela A G | | 0，，02： | 1 |
| 18 | Growth performance intestinal microbial populations of growing pigs fed diets containing sucrose thermal oligosaccharide caramel显示文摘 | Orban J I Patterson J A Adela O | 1997 | Journal of Animal Science1997，75，： | 1 |
| 19 | Comparative evaluation of liquid chromatography versus gas chromatography using a β -cyclodextrin stationary phase for the determination of BTEX in occupational environments 显示文摘 | ANDREU C C MARIA L E ADELA M A | 2009 | Talanta2009，78，45： | 1 |
| 20 | Chapter 2 Fasciola , Lymnaeids and Human Fascioliasis, with a Global Overview on Disease Transmission, Epidemiology, Evolutionary Genetics, Molecular Epidemiology and Control显示文摘 | Santiago Mas‐Coma María Adela Valero María Dolores Bargues | 2009 | Advances in Parasitology2009，，： | 1 |
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