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| 1 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 2 | 咽鼓管功能障碍定义、类型、临床表现及诊断的共识声明显示文摘1引言 英国NIHR卫生技术评估(HTA)计划发表的咽鼓管功能障碍治疗的系统回顾性研究指出,目前缺乏咽鼓管功能障碍统一的定义和诊断标准,推进这一领域研究进展的关键是针对咽鼓管功能障碍的诊断标准和重要临床结果达成共识。因此,2014年06月21日在荷兰阿姆斯特丹召开了由咽鼓管功能障碍领域的医学专家和科学家们参加的研讨会,旨在针对咽鼓管功能障碍的定义、临床表现、诊断及未来研究领域等方面达成共识。本文针对本次会议讨论结果总结如下。 | Schilder AG Bhutta MF Butler CC Holy C Levine LH Kvaerner KJ Norman G Pennings RJ Poe D Silvola JT Sudhoff H Lund VJ 翻曲腾飞 龚树生 | 2015 | 中国医学文摘(耳鼻咽喉科学)2015，30，6： | 5 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | 改进永磁同步电机转矩控制精度的措施显示文摘各种各样的实际因素会导致永磁同步电机在求取转矩时很难绝对精确。比如转子温升会导致磁场强度降低并使得输出转矩减小。导致转矩减小的另一种情况是在过载时铁心出现饱和。针对这样的情况,现在比较行之有效的设计思路是使用一个快速叠加速度控制环或者使用转矩传感器。但是,像绞车和注塑成型机一类的设备需要很高的转矩精度,而使用转矩传感器有诸多缺陷。本文将介绍三种不同的改进静态转矩精度的策略。第一种策略是基于对转矩常数和磁阻转矩常数的离线辨识。这一思想在第二种策略中得以扩展,即通过转矩与转距电流之间的关系来识别电机特性。这种策略通过采用多项式方程进行计算来补偿原开环控制的不足。第三种策略是一种在线自适应转矩常数控制技术,它基于对电机电参数的观测和对转速的测量。试验结果证实了三种策略理论的有效性。 | 薛靖 Dr.Guido Stoeppler Dr.Franz Bauer Siemens AG A&D MC Erlangen Germany | 2008 | 电力电子2008，6，1： | 2 |
| 5 | Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis:a case-control study显示文摘 | Bostom AG Shemin D Lapane KL | 1995 | Atherosclerosis1995，114，1： | 1 |
| 6 | Activation of toll-like receptor (TLR) 2, TLRA, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation 显示文摘 | Johnson AC Heinzel FP Diaconu E Sun Y Hise AG Golenbock D | 2005 | Invest Ophthalmol Vis Sci2005，46，2： | 1 |
| 7 | Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome显示文摘 | Bouros D Wells AU Nicholson AG | 2002 | Am J Respir Crit Care Med2002，165，12： | 1 |
| 8 | Effects of photodynamic therapy using verteporfin on experimental choroidal neovascularization and normal retina and choroid up to 7 w eeks after treatment显示文摘 | Husain D Kramer M Kenny AG | 1999 | Invest Ophthalmol Vis Sci1999，40，： | 1 |
| 9 | Knowledge, attitudes, and use of complementary and alternative therapies araong clinical nurse specialists in an academic medical center 显示文摘 | Cutshall S Derscheid D Miers AG | 2010 | Clin Nurse Spee2010，24，3： | 1 |
| 10 | Chemiluminescence detection of superoxide anion release and superoxide dis- mutase activity: modulation effect of Pulsatilla chinensis 显示文摘 | Yao D Vlessidis AG Gou Y | 2004 | Anal Bioanal Chem2004，379，1： | 1 |
| 11 | The history of Toll-like receptors-redefining innate immunity显示文摘 | ONeill LA Golenbock D Bowie AG | 2013 | Nat Rev Immunol2013，13，6： | 1 |
| 12 | Inflammasome-IL-1 -Th17 response in allergic lung inflammation 显示文摘 | Besnard AG Togbe D Couillin I | 2012 | J Mol Cell Biol2012，4，1： | 1 |
| 13 | The cystic fibrosis transmembrane regulator(CFTR) in the kidney显示文摘 | Morales MM Falkenstein D Lopes AG | 2000 | An Acad Bras Ci2000，72，3： | 1 |
| 14 | Ischemic preconditioning protects against cold ischemic injury through an oxidative stress dependent mechanism显示文摘 | Sindram D Rudiger HA Upadhya AG | 2002 | J Hepatol2002，36，1： | 1 |
| 15 | A theory based on free radical and radiation chemistry 显示文摘 | Haman D Aging | 1956 | J Gerontol1956，11，： | 1 |
| 16 | Malondialde-hyde( MDA) and protein carbonyl(PCO) levels as biomarkers of oxidativestress in subjects with familial hypercholesterolemia显示文摘 | Pirinccioglu AG Cdkalp D Pirinccioglu M | 2010 | Clin Biochem2010，43，15： | 1 |
| 17 | Treatment with interferon-a2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques 显示文摘 | Falzarano D de Wit E Rasmussen AL Feldmann F Oku- mura A Scott DP Brining D Bushmaker T Martellaro C Baseler L Benecke AG Katze MG Munster VJ Feldma- nn H | 2013 | Nat Med2013，19，10： | 1 |
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| 19 | Pig pancreatic islet transplantation into spontaneously diabetic dogs 显示文摘 | Abalovich AG Bacque MC Grana D | 2009 | Transplant Proc2009，41，1： | 1 |
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